A two-dimensional (2D) systems biology-based discrete liver tissue model: A simulation study with implications for ultrasound elastography of liver fibrosis.
A two-dimensional (2D) systems biology-based discrete liver tissue model: A simulation study with implications for ultrasound elastography of liver fibrosis.
复制标题
基于二维 (2D) 系统生物学的离散肝组织模型：一项对肝纤维化超声弹性成像具有影响的模拟研究。
DOI：
10.1016/j.compbiomed.2018.11.027
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发表时间：
2019
影响因子：
7.7
通讯作者：
Jiang,Jingfeng
中科院分区：
文献类型：
--
作者：
Wang,Yu;Jiang,Jingfeng
通常用于模拟或分析被成像的组织的机械特性的连续体组织模型在生物学上可能不现实。我们的主要目标是建立使用系统生物学来构建生物相关组织模型的可行性，将组织结构、组成和架构直接与超声测量相关联。第一个应用程序被指定为模拟肝纤维化组织。提出的肝组织模型利用了肝纤维化组织的组织病理学知识。特别地，源自分子组织病理学的系统生物学规则首先被实施到基于代理的软件平台SPARK中，以反映有/无脂肪变性的肝纤维化的进展。然后，将组织的微观成分（例如细胞成分）转换为计算网格（50-100 μm尺度），用于使用开源K-Wave进行波模拟。为了验证所提出的模型的物理合理性，进行虚拟波速测量（即剪切波速[SWS]和声速[SOS]）我们的初步结果表明，模拟的SWS值随着肝纤维化的进展而增加（从1.5 m/s [纤维化阶段1]到4 m/s [纤维化阶段4]）。同样，模拟的SOS值在临床数据范围内（从1575 m/s [纤维化0-3期]到1594 m/s [纤维化4期]）。综上所述，我们发现这些系统生物学模拟的有和没有脂肪变性的纤维化肝组织可以反映相关组织学的空间特征。此外，其机械特性（即剪切/压缩波速度）与临床文献中报告的数据一致。
Continuum tissue models that were often used to simulate or analyze the mechanical properties of tissues being imaged may not be biologically realistic. Our primary objective was to establish the feasibility of using systems biology to construct biologically relevant tissue models linking tissue structure, composition and architecture to the ultrasound measurements directly. The first application was designated to model fibrotic liver tissues.The proposed liver tissue model leveraged established histopathology knowledge of fibrotic liver tissues. Particularly, rules of systems biology derived from molecular histopathology were first implemented into an agent-based software platform SPARK to reflect progressions of liver fibrosis with/without steatosis. Then, microscopic compositions of tissues (e.g.cellular components) were converted to computing grids (at the 50–100 μm scale) for wave simulations using an open-source K-Wave. To verify the physical soundness of the proposed model, virtual wave speed measurements (i.e.shear wave speed [SWS] and the speed of sound [SOS]) were performed.Our initial results demonstrated that the simulated SWS values increased with the progression of liver fibrosis (from 1.5 m/s [Fibrosis stage 1] to 4 m/s [Fibrosis stage 4]). Similarly, the simulated SOS values were within the range of clinical data (from 1575 m/s [Fibrosis stage 0–3] to 1594 m/s [Fibrosis stage 4]).In summary, we found that those systems biology simulated fibrotic liver tissues with and without steatosis can reflect spatial characteristics of relevant histology. Also, their mechanical characteristics (i.e.shear/compressional wave speed) were in good agreement with data reported in the clinical literature.