Regulation of antigen-specific CD8+ T cell homeostasis by perforin and interferon-γ
Regulation of antigen-specific CD8+ T cell homeostasis by perforin and interferon-γ
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DOI：
10.1126/science.290.5495.1354
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发表时间：
2000-11-17
期刊：
影响因子：
56.9
通讯作者：
Harty, JT
中科院分区：
文献类型：
--
作者：
Badovinac, VP;Tvinnereim, AR;Harty, JT
T细胞记忆依赖于调节抗原刺激后这些细胞的扩增和死亡的因素。缺乏穿孔素和干扰素-γ（IFN-γ）的小鼠在感染单核细胞增生李斯特菌减毒株后表现出扩增增加，免疫优势改变，抗原特异性CD 8（+）T细胞死亡减少，这些小鼠被清除。CD 8（+）T细胞的扩增由穿孔素控制，而IFN-γ调节免疫优势和死亡阶段。因此，穿孔素和IFN-γ调节CD 8（+）T细胞稳态的不同元件，而不依赖于它们作为抗微生物效应分子的作用。
T cell memory depends on factors that regulate expansion and death of these cells after antigenic stimulation. Mice deficient in perforin and interferon-gamma (IFN-gamma) exhibited increased expansion, altered immunodominance, and decreased death of antigen-specific CD8(+) T cells after infection with an attenuated strain of Listeria monocytogenes, which was cleared from these mice. Expansion of CD8(+) T cells was controlled by perforin, whereas IFN-gamma regulated immunodominance and the death phase. Thus, perforin and IFN-gamma regulate distinct elements of CD8(+) T cell homeostasis independently of their role as antimicrobial effector molecules.