Amelioration of rCBF and PbtO2 following TBI at high altitude by hyperbaric oxygen pre-conditioning
Amelioration of rCBF and PbtO2 following TBI at high altitude by hyperbaric oxygen pre-conditioning
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DOI：
10.1179/174313209x414524
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发表时间：
2010-03-01
影响因子：
1.9
通讯作者：
Feng, Hua
中科院分区：
文献类型：
--
作者：
Hu, Shengli;Li, Fei;Feng, Hua
目的：高原低压缺氧可导致脑损伤，高压氧预处理可减轻缺血/缺氧性脑损伤。方法：将大鼠随机分为4组：高压氧预处理组（HBOP，n=10）、高原组（HA，n = 10）、平原对照组（PC，n= 10）和平原假手术组（sham，n=10）。除假手术组外，其余各组均采用重物坠落装置造成头部创伤。结果：HA组大鼠神经功能缺损评分最高，HBOP组次之，PC组最低。HA组rCBF和PbtO（2）均最低。结论：高压氧预处理可明显减轻高原TBI大鼠脑组织的损伤，其机制可能与改善脑组织rCBF和PbtO（2）有关。HBO预处理可能对前往高海拔地区的人有益。
Objectives: Hypobaric hypoxia at high altitude can lead to brain damage and pre-conditioning with hyperbaric oxygen (HBO) can reduce ischemic/hypoxic brain injury. This study investigates the effects of high altitude on traumatic brain injury (TBI) and examines the neuroprotection provided by HBO preconditioning against TBI.Methods: Rats were randomly divided into four groups: HBO pre-conditioning group (HBOP, n=10), high altitude group (HA, n=10), plain control group (PC, n=10) and plain sham operation group (sham, n=10). All groups were subjected to head trauma by weight drop device except for the sham group. Rats from each group were examined for neurological function, regional cerebral blood flow (rCBF) and brain tissue oxygen pressure (PbtO(2)) and were killed for analysis by transmission electron microscope.Results: The score of neurological deficits in the HA group was highest, followed by the HBOP group and the PC group, respectively. Both rCBF and PbtO(2) were the lowest in the HA group. Brain morphology and structure seen via the transmission electron microscope was diminished in the HA group, while fewer pathological injuries occurred in the HBOP and PC groups.Conclusions: High altitude aggravates TBI significantly and HBO pre-conditioning can attenuate TBI in rats at high altitude by improvement of rCBF and PbtO(2). Pre-treatment with HBO might be beneficial for people traveling to high altitude locations.