Gut Microbiota and Predicted Metabolic Pathways in a Sample of Mexican Women Affected by Obesity and Obesity Plus Metabolic Syndrome
Gut Microbiota and Predicted Metabolic Pathways in a Sample of Mexican Women Affected by Obesity and Obesity Plus Metabolic Syndrome
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DOI：
10.3390/ijms20020438
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发表时间：
2019-01-02
影响因子：
5.6
通讯作者：
Hernandez-Guerrero, Cesar
中科院分区：
文献类型：
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作者：
Chavez-Carbajal, Alejandra;Nirmalkar, Khemlal;Hernandez-Guerrero, Cesar
肥胖是一种过度的脂肪积累，可能导致代谢综合征等并发症。有关于肠道微生物群和代谢综合征与饮食，宿主遗传学和其他环境因素的报告;然而，有必要探索肠道微生物群代谢途径在墨西哥人等人群中的作用，其中肥胖和代谢综合征的患病率很高。这项研究确定了健康墨西哥女性（CO），肥胖女性（OB）和肥胖加代谢综合征（OMS）女性样本中肠道微生物群的变化。我们研究了67名妇女，通过高通量DNA测序表征她们的人体测量和生化参数沿着以及她们的肠道细菌多样性。我们的研究结果表明，在OB或OMS妇女，厚壁菌门是最丰富的细菌门。我们观察到属于瘤胃球菌科，毛螺菌科和丹毒科的细菌丰度的显着变化和显着富集的肠道细菌从16个不同的分类群，可能解释观察到的代谢组之间的变化。最后，在每个类别中发现的肠道微生物群的预测功能宏基因组显示了与脂质代谢相关的代谢途径的差异。我们证明，墨西哥妇女有一个特定的细菌肠道微生物群特征的每种表型。存在可能解释组之间观察到的代谢差异的细菌，并且OMS和OB条件下的肠道细菌携带更多涉及脂质代谢的代谢途径的基因。
Obesity is an excessive fat accumulation that could lead to complications like metabolic syndrome. There are reports on gut microbiota and metabolic syndrome in relation to dietary, host genetics, and other environmental factors; however, it is necessary to explore the role of the gut microbiota metabolic pathways in populations like Mexicans, where the prevalence of obesity and metabolic syndrome is high. This study identify alterations of the gut microbiota in a sample of healthy Mexican women (CO), women with obesity (OB), and women with obesity plus metabolic syndrome (OMS). We studied 67 women, characterizing their anthropometric and biochemical parameters along with their gut bacterial diversity by high-throughput DNA sequencing. Our results indicate that in OB or OMS women, Firmicutes was the most abundant bacterial phylum. We observed significant changes in abundances of bacteria belonging to the Ruminococcaceae, Lachnospiraceae, and Erysipelotrichaceae families and significant enrichment of gut bacteria from 16 different taxa that might explain the observed metabolic alterations between the groups. Finally, the predicted functional metagenome of the gut microbiota found in each category shows differences in metabolic pathways related to lipid metabolism. We demonstrate that Mexican women have a particular bacterial gut microbiota characteristic of each phenotype. There are bacteria that potentially explain the observed metabolic differences between the groups, and gut bacteria in OMS and OB conditions carry more genes of metabolic pathways implicated in lipid metabolism.