5-hydroxytryptamine and precapillary vessels.
5-hydroxytryptamine and precapillary vessels.
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5-羟色胺和毛细血管前血管。
DOI：
10.1007/978-1-4615-9173-3_10
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发表时间：
1983
期刊：
影响因子：
--
通讯作者：
Van Nueten Jm
中科院分区：
文献类型：
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作者：
Van Nueten Jm
5-羟色胺 (5-HT) 血管作用的复杂性可以通过不同来源的动脉组织对胺的敏感性差异来说明。 5-HT 与 5-HT2 受体的相互作用受到特定拮抗剂（例如酮色林和美西麦角）的抑制。此类化合物还抑制对聚集血小板释放的内源性5-HT的收缩反应。如果所使用的拮抗剂不具有部分激动特性，则在存在血清素能阻断的情况下，可以揭示对 5-HT 反应的血管舒张成分。 5-HT 增强（放大）对肾上腺素能和非肾上腺素能神经体液介质的血管收缩反应。单胺的放大作用可被 5-HT2-5-羟色胺拮抗剂（例如酮舍林）阻止。
The complexity of the vascular effects of 5-hydroxytryptamine (5-HT) is illustrated by differences in sensitivity to the amine among arterial tissues of different origin. The interaction of 5-HT with 5-HT2 receptors is inhibited by specific antagonists such as ketanserin and methysergide. Such compounds also inhibit the contractile responses to endogenous 5-HT released from aggregating platelets. The vasodilator component of the response to 5-HT can be unmasked in the presence of serotonergic blockade, provided the antagonist used has no partial agonistic properties. 5-HT augments (amplifies) the vasoconstrictor responses to adrenergic and nonadrenergic neurohumoral mediators. The amplifying effect of the monoamine is prevented by 5-HT2-serotonergic antagonists such as ketanserin.