TEMPERATURE-SENSITIVE NEURONES IN DOGS HYPOTHALAMUS
TEMPERATURE-SENSITIVE NEURONES IN DOGS HYPOTHALAMUS
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DOI：
10.1113/jphysiol.1964.sp007515
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发表时间：
1964-01-01
影响因子：
5.5
通讯作者：
SUTHERLAND, K
中科院分区：
文献类型：
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作者：
HARDY, JD;HELLON, RF;SUTHERLAND, K
微电极已被用于狗的下丘脑前部，以寻找对微小温度变化敏感的神经元。热敏管被植入被探测区域的侧面，使局部温度升高或降低。在前连合底与视交叉之间的中线2毫米范围内进行搜索。下丘脑温度升高或降低1-2℃对约60%的单位的放电率没有影响。其余80%的神经元对温度变化表现出敏感性，加热时放电速率增加，冷却时放电速率降低。发射速率随温度变化的速率变化相当平稳，平均灵敏度为7脉冲/秒。C.没有适应的证据。20%的敏感细胞在冷却后放电速率增加。一些单元平稳地跟随温度波动，而另一些则表现出突然爆发或随着冷却的阶段性响应。这些敏感细胞可能是在温度调节中起重要作用的受体。
Micro-eIectrodes have been used in dogs to explore the anterior hypothalamus for neurones which were sensitive to small temperature changes. Thermode tubes were implanted lateral to the region being explored and enabled local temperature to be raised or lowered. Searches were made within 2 mm of the mid-line between the base of the anterior commissure and the optic chiasma. Raising or lowering the hypothalamic temperature by 1-2[degree] C had no effect on the firing rate of about 60% of the units. 80% of the remaining neurones showed a sensitivity to temperature changes by increased firing rate on heating and decreased with cooling. Firing rate followed different rates of change of temperature quite smoothly and with a mean sensitivity of 7 impulses/sec. [degree] C. There was no evidence of adaptation. 20% of the sensitive cells increased their firing rate with cooling. Some of the units followed the temperature swings smoothly but others showed an abrupt outburst or phasic response with cooling. It is suggested that the sensitive cells are receptors which play an important role in temperature regulation.