Trisodium trimetaphosphate crosslinked xanthan networks: synthesis, swelling, loading and releasing behaviour
Trisodium trimetaphosphate crosslinked xanthan networks: synthesis, swelling, loading and releasing behaviour
复制标题
DOI：
10.1007/s00289-008-0033-8
复制
发表时间：
2009-04-01
期刊：
影响因子：
3.2
通讯作者：
Le Cerf, Didier
中科院分区：
文献类型：
--
作者：
Bejenariu, Anca;Popa, Marcel;Le Cerf, Didier
黄原胶（Xan）是一种具有生物相容性和生物可降解性的多糖，具有作为药物控释应用的基质的潜力。以三偏磷酸三钠（STMP）为交联剂，在碱性介质中合成了黄原胶水凝胶。合成了具有不同交联剂/聚合物比例的水凝胶，并随后通过元素分析和动态溶胀度、模型化合物负载和释放行为的手段对其进行表征。两个物理参数（交联密度和磷酸盐电荷）通过硬化或破坏三维大分子系综表现出拮抗作用。使用中间STMP：Xan比率获得最高溶胀度，在这种情况下，两种力的相反作用很好地平衡。合成的网络是pH敏感的。在酸性和碱性介质中的溶胀度是较低的中性pH值相比。捕获和释放行为的新合成的黄原胶网络进行了研究，使用亚甲基蓝作为阳离子模型分子。释放动力学符合一级动力学模型。
Xanthan (Xan) is a biocompatible and biodegradable polysaccharide with a promising potential as substrate for controlled drug delivery applications. Xan based hydrogels were synthesized in alkaline medium using trisodium trimetaphosphate (STMP) as crosslinking agent. Hydrogels with various crosslinking agent/polymer ratios were synthesized and subsequently characterized by the means of elemental analysis and dynamic swelling degree, model compound loading and releasing behaviour. Two physical parameters (crosslinking density and phosphate charge) are manifesting antagonistic actions by stiffening or disrupting the three-dimensional macromolecular ensemble. The highest swelling degree was obtained using an intermediate STMP:Xan ratio in which case the opposing effects of the two forces are well balanced. The synthesized networks are pH sensitive. In acid and alkaline media the swelling degrees are lower by comparison to neutral pH. The entrapping and releasing behaviour of the newly synthesized xanthan networks were studied using methylene blue as a cationic model molecule. The releasing kinetics present a first-order model.