Elevation of postmortem triiodothyronine in sudden infant death syndrome and in infants who died of other causes: a marker of previous health.
Elevation of postmortem triiodothyronine in sudden infant death syndrome and in infants who died of other causes: a marker of previous health.
复制标题
婴儿猝死综合症和因其他原因死亡的婴儿死后三碘甲状腺原氨酸升高：以前健康的标志。
DOI：
10.1016/s0022-3476(83)80520-4
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发表时间：
1983
期刊：
影响因子：
--
通讯作者：
Hillman,LS
中科院分区：
文献类型：
--
作者：
Schwarz,EH;Chasalow,FI;Erickson,MM;Hillman,RE;Yuan,M;Hillman,LS
我们测定了62例婴儿猝死综合征（SIDS）患者、30例已知原因死亡的婴儿和15例对照组的血清甲状腺素（T4）、三碘甲状腺原氨酸（T3）、游离T4、促甲状腺激素和皮质醇浓度。平均T3值在69%的SIDS患者中升高，在37%的其他死亡婴儿中升高，而在对照组婴儿中没有升高。在排除那些已知死因的甲状腺功能异常（T4、游离T4或反T3死后浓度异常）的患者后，63%的患者T3值升高。当根据病例历史和尸检结果分析数据时，那些健康状况良好但意外死亡的婴儿的平均T3升高与SIDS受害者相似;那些在已知改变甲状腺代谢的条件下死亡的婴儿则没有。T4、游离T4、反向T3、促甲状腺激素和皮质醇值在区分SIDS患者与对照组或死亡时健康的患者方面没有用处。我们无法找到任何差异T3血清浓度之间的总组谁有SIDS和那些谁有SIDS轻微感染，与瘀点的胸腔内器官，早产，或那些谁复苏。我们的数据指出了在评估小岛屿发展中国家时使用适当控制的重要性。SIDS的正常反向T3值，以及正常T4和游离T4值的确认，构成了对慢性持续性肺泡静脉功能减退或长时间缺氧发作的证据，就在SIDS死亡之前。
We measured serum concentrations of thyroxine (T4), triiodothyronine (T3), free T4,thyroid-stimulating hormone, and cortisol in 62 victims of sudden infant death syndrome (SIDS) in 30 infants who died of known causes and in 15 living controls. The mean T3value was elevated in 69% of those with SIDS, 37% of the others who died, and in no control infants. After excluding those who died of known cause who had abnormal thyroid function (abnormal postmortem concentrations of T4, free T4, or reverse T3), the T3values were elevated in 63% of those remaining. When the data were analyzed on the basis of case histories and autopsy findings, those infants who were in good health and died suddenly of accidental causes had an elevation in mean T3similar to that seen in SIDS victims; those who died under conditions known to alter thyroid metabolism did not. The T4, free T4, reverse T3, thyroid-stimulating hormone, and cortisol values were not useful in differentiating those with SIDS from the living controls, or those who were healthy at the time of death. We were unable to find any difference in T3serum concentrations between the total group who had SIDS and those who had SIDS with minor infections, with petechiae on intrathoracic organs, with premature birth, or those who were resuscitated. Our data point out the importance of using appropriate controls when evaluating SIDS. The normal reverse T3values in SIDS, as well as confirmation of the normal T4and free T4values, constitute evidence against chronic persistent alveolar hypovenilation or prolonged episodes of hypoxia immediately preceding death from SIDS.