Antinociceptive effects of galanin in the central nucleus of amygdala of rats, an involvement of opioid receptors
Antinociceptive effects of galanin in the central nucleus of amygdala of rats, an involvement of opioid receptors
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DOI：
10.1016/j.brainres.2009.12.060
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发表时间：
2010-03-12
期刊：
影响因子：
2.9
通讯作者：
Yu, Long-Chuan
中科院分区：
文献类型：
--
作者：
Jin, Wu-Yang;Liu, Zhuo;Yu, Long-Chuan
杏仁核中央核（central nucleus of amygdala，CeA）是一个非常重要的脑结构，参与多种生理功能，尤其是痛觉调制。在CeA中发现了高密度的甘丙肽和甘丙肽受体。本研究旨在探讨甘丙肽在大鼠脑前区的抗伤害效应，以及阿片受体在甘丙肽抗伤害效应中的作用。CeA内注射甘丙肽可诱导大鼠对有害的热刺激和机械刺激的后爪退缩延迟（HWL）呈剂量依赖性增加。有趣的是，脑内注射甘丙肽诱导的镇痛作用被脑内注射纳洛酮（一种常见的阿片受体拮抗剂）阻断，表明阿片受体参与了甘丙肽诱导的大鼠脑内镇痛作用。此外，CeA内注射选择性μ-阿片受体拮抗剂β-funaltamine（β-FNA）或δ-阿片受体拮抗剂纳曲吲哚，但不是κ-阿片受体拮抗剂nor-binaltorphimine（nor-BNI），显着减弱甘丙肽诱导的大鼠CeA中HWL的增加。两者合计，结果表明，甘丙肽诱导大鼠CeA的镇痛作用，μ-和δ-阿片受体参与甘丙肽诱导的镇痛。(C)2009 Elsevier B. V.保留所有权利。
The central nucleus of amygdala (CeA) is a very important brain structure involved in multiple physiological functions, especially in pain modulation. There are high densities of galanin and galanin receptors found in the CeA. The present study was performed to explore the antinociceptive effects of galanin in the CeA of rats, and possible involvements of opioid receptors in the galanin-induced antinociception. Intra-CeA injection of galanin induced dose-dependent increases in hindpaw withdrawal latencies (HWLs) to noxious thermal and mechanical stimulations in rats. Interestingly, the amtinociceptive effect induced by intra-CeA injection of galanin was blocked by intra-CeA injection of naloxone, a common opioid receptor antagonist, indicating an involvement of opioid receptors in the galanin-induced antinociception in the CeA of rats. Moreover, intra-CeA injection of either selective mu-opioid receptor antagonist beta-funaltrexamine (beta-FNA) or delta-opioid receptor antagonist naltrindole, but not kappa-opioid receptor antagonist nor-binaltorphimine (nor-BNI), significantly attenuated the galanin-induced increases in HWLs in the CeA of rats. Taken together, the results demonstrate that galanin induces antinociceptive effects in the CeA of rats, and both mu- and delta-opioid receptors are involved in the galanin-induced antinociception. (C) 2009 Elsevier B.V. All rights reserved.