Thinking big with small molecules.

Thinking big with small molecules.
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小分子大思维。

DOI:
10.1083/jcb.201501084
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发表时间:
2015
期刊:
The Journal of cell biology
影响因子:
--
通讯作者:
Chen,JamesK
Chen,JamesK
中科院分区:
--
文献类型:
--
作者:
Mruk,Karen;Chen,JamesK

文献摘要

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合成化学使科学家能够探索细胞生物学的前沿,仅受化学键合和反应性定律的限制。当我们研究日益复杂的生物学问题时,新的化学技术可以提供细胞功能的系统水平视图。在这里,我们讨论了一些分子探针,说明这种转变,从“一个化合物,一个基因”的范例,以更综合的方法,细胞生物学。
Synthetic chemistry has enabled scientists to explore the frontiers of cell biology, limited only by the laws of chemical bonding and reactivity. As we investigate biological questions of increasing complexity, new chemical technologies can provide systems-level views of cellular function. Here we discuss some of the molecular probes that illustrate this shift from a “one compound, one gene” paradigm to a more integrated approach to cell biology.