The Sigma-1 Receptor as a Pluripotent Modulator in Living Systems.
The Sigma-1 Receptor as a Pluripotent Modulator in Living Systems.
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DOI：
10.1016/j.tips.2016.01.003
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发表时间：
2016-04
影响因子：
13.8
通讯作者：
Tsai SY
中科院分区：
文献类型：
--
作者：
Su TP;Su TC;Nakamura Y;Tsai SY
sigma-1受体（Sig-1 R）是一种内质网（ER）蛋白，特异性地位于ER和线粒体之间的界面，称为MAM，其中Sig-1 R最近被报道参与某些CNS疾病。除了能够转移到质膜与离子通道和其他受体相互作用外，发现Sig-1 R存在于核膜中，在核膜中招募染色质重塑因子以影响基因的转录。同样，通过实验和生物信息学手段，据报道Sig-1 Rs与其他基因座（包括胞质溶胶）的其他膜蛋白或可溶性蛋白相互作用。我们提出，Sig-1 R是一种多能调节剂，在生命系统中具有多种功能表现。
The sigma-1 receptor (Sig-1R) is an endoplasmic reticulum (ER) protein resides specifically at the interface between ER and mitochondria, called the MAM, where the Sig-1R is recently reported to be involved in certain CNS diseases. In addition to being able to translocate to the plasma membrane to interact with ion channels and other receptors, the Sig-1R is found to exist at the nuclear envelope where it recruits chromatin-remodeling factors to affect the transcription of genes. As well, thorough experimental and bioinformatic means, Sig-1Rs are reported to interact with other membranous or soluble proteins at other loci, including the cytosol. We propose that the Sig-1R is a pluripotent modulator with resultant multiple functional manifestations in the living system.