Dissociable Identity- and Modality-Specific Neural Representations as Revealed by Cross-Modal Nonspatial Inhibition of Return
Dissociable Identity- and Modality-Specific Neural Representations as Revealed by Cross-Modal Nonspatial Inhibition of Return
复制标题
跨模态非空间回归抑制揭示的可分离身份和模态特异性神经表征
DOI：
10.1002/hbm.22454
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发表时间：
2014-08-01
影响因子：
4.8
通讯作者：
Chen, Qi
中科院分区：
文献类型：
--
作者：
Chi, Yukai;Yue, Zhenzhu;Chen, Qi
关于物体概念在人脑中是基于超模态同一性的表征还是特定模态的表征，一直存在争议。在这项功能磁共振成像研究中，我们采用了跨模态的“启动-中性线索-目标”语义启动范式，其中启动-目标关系沿着身份和模态维度进行操纵。启动和目标可以指相同或不同的语义身份，并且可以通过相同或不同的感觉模态来传递。通过计算这2个变量的主效应和交互作用，（身份提示有效性：“Identity_Cued”vs.“Identity_Uncued”）x 2（情态线索效度：“Modality_Cued”vs.“Modality_Uncued”）析因设计，我们旨在分离三个神经网络，这些神经网络参与创建独立于感觉模态的新的身份特异性表征，参与创建独立于语义身份的模态特异性表征，以及分别评估对象沿着身份和模态维度的变化。我们的研究结果表明，双侧外侧枕叶皮层参与创建一个新的超模态语义表征，而与输入模态无关，左侧背侧运动前皮层和左侧顶内沟参与创建一个新的模态特异性表征，而与其语义身份无关，当同一性和通道性同时被提示或同时未被提示时，双侧上级颞沟参与了表征的形成。此外，右额下回只有当目标的身份和形式都是新的时才表现出增强的神经活动，这表明它在新奇检测中的功能作用。(c)2014 Wiley Periodicals，Inc.
There are ongoing debates on whether object concepts are coded as supramodal identity based or modality-specific representations in the human brain. In this fMRI study, we adopted a cross modal "prime-neutral cue-target" semantic priming paradigm, in which the prime-target relationship was manipulated along both the identity and the modality dimensions. The prime and the target could refer to either the same or different semantic identities, and could be delivered via either the same or different sensory modalities. By calculating the main effects and interactions of this 2 (identity cue validity: "Identity_Cued" vs. "Identity_Uncued") x 2 (modality cue validity: "Modality_Cued" vs. "Modality_Uncued") factorial design, we aimed at dissociating three neural networks involved in creating novel identity-specific representations independent of sensory modality, in creating modality specific representations independent of semantic identity, and in evaluating changes of an object along both the identity and the modality dimensions, respectively. Our results suggested that bilateral lateral occipital cortex was involved in creating a new supramodal semantic representation irrespective of the input modality, left dorsal premotor cortex, and left intraparietal sulcus were involved in creating a new modality-specific representation irrespective of its semantic identity, and bilateral superior temporal sulcus was involved in creating a representation when the identity and modality properties were both cued or both uncued. In addition, right inferior frontal gyrus showed enhanced neural activity only when both the identity and the modality of the target were new, indicating its functional role in novelty detection. (c) 2014 Wiley Periodicals, Inc.