The hyaluronic acid-binding protease: A novel vascular and inflammatory mediator?
The hyaluronic acid-binding protease: A novel vascular and inflammatory mediator?
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DOI：
10.1016/j.intimp.2007.10.012
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发表时间：
2008-02-01
影响因子：
5.6
通讯作者：
Dodt, Johannes
中科院分区：
文献类型：
--
作者：
Etscheid, Michael;Kress, Julia;Dodt, Johannes
人血浆中的一种丝氨酸蛋白酶，称为透明质酸结合酶HABP，在结构上与纤溶酶原激活剂、凝血因子II和肝细胞生长因子激活剂有关。这种蛋白水解酶具有与凝血和纤溶相关的活性，尽管在止血方面的生理作用仍有待证实。最近几年，越来越多的信息支持这样的假设，即HABP在调节血管系统和血管周围环境中的细胞方面也发挥着重要作用。一方面，HABP在人脐静脉内皮细胞表面产生缓激肽或碱性成纤维细胞生长因子，通过缓激肽受体2和FGFR-1触发细胞内信号转导。其他数据表明，除内皮细胞外，血管平滑肌细胞也是HABP的靶细胞。作为细胞调节的主要机制，HABP对生长因子具有很高的亲和力，随后发生蛋白分解和失活。本文综述了HABP作为一种血管和可能的炎症介质的生理学和临床相关性的研究现状。(C)2007 Elsevier B.V.保留所有权利。
A serine protease in human plasma termed hyaluronan-binding protease HABP is structurally related to plasminogen-activators, coagulation FXII and hepathocyte growth factor activator. This protease has coagulation and fibrinolysis-related activities, although a physiologic role in haemostasis still requires confirmation. In more recent years accumulating information became available supporting the hypothesis that HABP plays also a significant role in the regulation of cells in the vasculature and in the perivascular environment. On the one hand HABP generates bradykinin or bFGF on the surface of human umbilical vein endothelial cells (HUVECs), triggering intracellular signalling via the bradykinin receptor 2 and FGFR-1. Other data indicate that beside endothelial cells also vascular smooth muscle cells are a target for HABP. As major mechanism of cell regulation a high affinity of HABP to growth factors with the subsequent proteolytic cleavage and inactivation has been identified. The current knowledge of the physiologic and clinical relevance of HABP as a vascular and possibly inflammatory mediator is summarized in this review. (c) 2007 Elsevier B.V. All rights reserved.