RELAPSE PHENOMENA OF SPIRONEMA RECURRENTIS.
RELAPSE PHENOMENA OF SPIRONEMA RECURRENTIS.
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螺旋藻复发的复发现象。
DOI：
10.1084/jem.48.1.65
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发表时间：
1928-06-30
影响因子：
15.3
通讯作者：
Meleney, HE
中科院分区：
文献类型：
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作者：
Meleney, HE
1.发现松鼠和花栗鼠易感染华北回归螺旋体，但在正常动物中无复发。2.脾切除术导致感染强度增加，并出现一次或两次复发。3.通过用一种人类螺旋体菌株感染切除脾脏的松鼠，由于复发而产生了六种不同的菌株。4.在观察期间，菌株均保持其特异的凝集特性。最老的菌株观察了132天，并通过38次转移，该菌株最后分离了22天，并通过6次转移。5.复发的菌株序列并不总是相同的。有时会产生新的菌株，有时又会回复到旧的菌株。6.菌株之间建立了一定的关系。相关的菌株总是那些出现，或理论上可能出现，在交替的攻击。只有一个病例在两次连续发作中出现了相关菌株。7.没有切除脾脏的松鼠只有一次攻击，并且只对接种的菌株或密切相关的菌株产生免疫物质。通过再接种，这种松鼠可能连续感染多达四种不同的菌株。8.脾脏对松鼠复发的发展有保护作用，但显然不控制特异性免疫物质的形成。9.根据所记录的观察结果，建议对回归热的临床过程进行解释。10.目前，没有理由将回归热的螺旋体分为不同的种类。
1. Squirrels and chipmunks were found to be susceptible to infection with the Spironema recurrentis of North China, but no relapses occurred in normal animals. 2. Splenectomy caused an increase in the intensity of the infection and the appearance of one or two relapses. 3. By inoculating splenectomized squirrels with a single human strain of spirochetes, six different strains were produced as a result of relapses. 4. The strains all retained their specific agglutinating characteristics during the period of observation. The oldest strain was observed for 132 days and through 38 transfers, the strain last isolated for 22 days and through 6 transfers. 5. The sequence of strains in relapses was not always the same. Sometimes new strains were produced, at other times there was reversion to an older strain. 6. Certain relationships between strains were established. The related strains were always those which appeared, or theoretically might have appeared, in alternate attacks. In only one case did related strains appear in two consecutive attacks. 7. Squirrels whose spleens were not removed had only one attack and developed immune substances only against the strain inoculated or against closely related strains. It was possible by reinoculation to produce infection in such squirrels with as many as four different strains in succession. 8. The spleen has a protective influence against the development of the relapse in the squirrel, but apparently does not control the formation of specific immune substances. 9. An explanation of the clinical course of relapsing fever is suggested on the basis of the observations recorded. 10. There is, at present, no justification for the division of the spirochetes of relapsing fever into different species.
DOI：
10.1007/bf01732270
发表时间：
1925-01-01
期刊：
Klinische Wochenschrift
影响因子：
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作者：
Kroo, H.
通讯作者：
Kroo, H.