Mechanisms of Antibacterial Activity of MgO: Non-ROS Mediated Toxicity of MgO Nanoparticles Towards Escherichia coli
Mechanisms of Antibacterial Activity of MgO: Non-ROS Mediated Toxicity of MgO Nanoparticles Towards Escherichia coli
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DOI：
10.1002/smll.201302434
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发表时间：
2014-03-01
期刊：
影响因子：
13.3
通讯作者：
Leung, Frederick C. C.
中科院分区：
文献类型：
--
作者：
Leung, Yu Hang;Ng, Alan M. C.;Leung, Frederick C. C.
金属氧化物纳米材料的毒性及其抗菌活性越来越受到人们的关注。在这些材料中，MgO作为低成本、环境友好的材料特别令人感兴趣。与其他金属氧化物纳米材料类似，MgO的毒性通常归因于活性氧（ROS）的产生。我们研究了三种不同的MgO纳米颗粒样品的毒性，并且清楚地证明了两种MgO纳米颗粒样品在不产生ROS的情况下对大肠杆菌细菌细胞的稳健毒性。蛋白质组学数据也清楚地表明，没有氧化应激，并表明细胞死亡的主要机制是有关的细胞膜损伤，这似乎不是由于脂质过氧化。
The toxicity of metal oxide nanomaterials and their antimicrobial activity is attracting increasing attention. Among these materials, MgO is particularly interesting as a low cost, environmentally-friendly material. The toxicity of MgO, similar to other metal oxide nanomaterials, is commonly attributed to the production of reactive oxygen species (ROS). We investigated the toxicity of three different MgO nanoparticle samples, and clearly demonstrated robust toxicity towards Escherichia coli bacterial cells in the absence of ROS production for two MgO nanoparticle samples. Proteomics data also clearly demonstrate the absence of oxidative stress and indicate that the primary mechanism of cell death is related to the cell membrane damage, which does not appear to be due to lipid peroxidation.