Differential patterns of blood oxygenation in the prefrontal cortex between patients with methamphetamine-induced psychosis and schizophrenia.
Differential patterns of blood oxygenation in the prefrontal cortex between patients with methamphetamine-induced psychosis and schizophrenia.
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DOI：
10.1038/srep12107
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发表时间：
2015-07-16
影响因子：
4.6
通讯作者：
Kishimoto T
中科院分区：
文献类型：
--
作者：
Yamamuro K;Makinodan M;Kimoto S;Kishimoto N;Morimoto T;Toritsuka M;Matsuoka K;Takebayashi Y;Takata T;Takahashi M;Tanimura Y;Nishihata Y;Matsuda Y;Ota T;Yoshino H;Iida J;Kishimoto T
尽管在精神病学上有一些轻微的差异，但甲基苯丙胺诱导的精神病（MAP）与精神分裂症的鉴别诊断可能具有挑战性，因为这两种疾病的临床症状存在很大的重叠。然而，最近的一项研究表明，在认知任务期间进行的近红外光谱（NIRS）可以成为区分这两种疾病的有力工具。在这里，我们评估了语言流畅性任务的表现在近红外光谱在15例MAP和19例精神分裂症患者的年龄和性别匹配。我们使用前额叶探头和24通道近红外光谱仪测量氧合血红蛋白的相对浓度，每0.1秒的任务。采用阳性与阴性症状量表（PANSS）和精神分裂症认知功能简明评定量表（BACS）评定患者的神经认知功能和临床精神病理学。与精神分裂症组相比，MAP组前额叶皮质的氧合血红蛋白变化显着较高，特别是在右侧背外侧前额叶皮质。相反，我们发现PANSS和BACS评分无显著差异。我们的研究结果表明，近红外光谱测量可用于区分MAP患者与精神分裂症患者，即使在临床症状相似的情况下。
Despite some slight differences in symptomatology, differential diagnosis of methamphetamine-induced psychosis (MAP) versus schizophrenia can be challenging because both disorders present a large overlap in their clinical symptoms. However, a recent study has shown that near-infrared spectroscopy (NIRS) performed during a cognitive task can be a powerful tool to differentiate between these two disorders. Here, we evaluated verbal fluency task performance during NIRS in 15 patients diagnosed with MAP and 19 with schizophrenia matched for age and sex. We used prefrontal probes and a 24-channel NIRS machine to measure the relative concentrations of oxyhaemoglobin every 0.1 s during the task. For each patient, the neurocognitive function and clinical psychopathology were evaluated using the Positive and Negative Symptom Scale (PANSS), and the Brief Assessment of Cognition in Schizophrenia (BACS). Oxyhaemoglobin changes in the prefrontal cortex were significantly higher in the MAP group compared to those in the schizophrenia group, particularly in the right dorsolateral prefrontal cortex. In contrast, we found no significant difference in PANSS and BACS scores. Our findings suggest that NIRS measurement could be applied to differentiate patients with MAP from those with schizophrenia, even in cases where clinical symptoms are similar.