Gastric emptying of a liquid nutrient meal in the critically ill: relationship between scintigraphic and carbon breath test measurement
Gastric emptying of a liquid nutrient meal in the critically ill: relationship between scintigraphic and carbon breath test measurement
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DOI：
10.1136/gut.2010.227934
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发表时间：
2011-10-01
期刊：
影响因子：
24.5
通讯作者：
Horowitz, M.
中科院分区：
文献类型：
--
作者：
Chapman, M. J.;Besanko, L. K.;Horowitz, M.
目的据推测，胃排空延迟(GE)在危重病中经常发生；然而，慢胃排空的患病率以前并未通过核素扫描进行评估。此外，呼气测试可能会提供一种方便的量化GE的方法，但在这种情况下尚未得到验证。本研究的目的是(I)确定延迟GE在未选择的危重病患者中的患病率以及(Ii)评估核素扫描和碳呼气试验测量的GE之间的关系。设计前瞻性观察研究。设置内外科混合重症监护病房。患者25例未选择的机械通气患者(年龄66岁(49-72岁)；14例健康受试者(年龄62岁(19-84))。用~(14)C辛酸和~(99m)Tm硫胶体标记的100ml标准液体饲料经鼻胃管放置于胃内，测定60、120、180和240min的胃“餐”滞留、呼吸试验t(50)(BTT(50))和GE系数。结果24例患者中12例(50%)GE延迟120min。呼气试验与核素扫描有很好的相关性(120分钟滞留率vsBTt50；r(2)=0.57健康人；r(2)=0.56患者；p
Objective It is assumed that delayed gastric emptying (GE) occurs frequently in critical illness; however, the prevalence of slow GE has not previously been assessed using scintigraphy. Furthermore, breath tests could potentially provide a convenient method of quantifying GE, but have not been validated in this setting. The aims of this study were to (i) determine the prevalence of delayed GE in unselected, critically ill patients and (ii) evaluate the relationships between GE as measured by scintigraphy and carbon breath test.Design Prospective observational study.Setting Mixed medical/surgical intensive care unit.Patients 25 unselected, mechanically ventilated patients (age 66 years (49-72); and 14 healthy subjects (age 62 years (19-84)).Interventions GE was measured using scintigraphy and 14 C-breath test. A test meal of 100 ml Ensure (standard liquid feed) labelled with 14 C octanoic acid and (99m)Technetium sulphur colloid was placed in the stomach via a nasogastric tube.Main outcome measures Gastric 'meal' retention (scintigraphy) at 60, 120, 180 and 240 min, breath test t(50) (BTt(50)), and GE coefficient were determined.Results Of the 24 patients with scintigraphic data, GE was delayed at 120 min in 12 (50%). Breath tests correlated well with scintigraphy in both patients and healthy subjects (% retention at 120 min vs BTt50; r(2)=0.57 healthy; r(2)=0.56 patients; p