The clinical and immunological features of patients with combined anti-glomerular basement membrane disease and membranous nephropathy
The clinical and immunological features of patients with combined anti-glomerular basement membrane disease and membranous nephropathy
复制标题
抗肾小球基底膜病合并膜性肾病患者的临床及免疫学特征
DOI：
10.1038/ki.2013.364
复制
发表时间：
2014-04-01
影响因子：
19.6
通讯作者：
Zhao, Ming-hui
中科院分区：
文献类型：
--
作者：
Jia, Xiao-yu;Hu, Shui-yi;Zhao, Ming-hui
The association of anti-glomerular basement membrane (GBM) disease, also known as Goodpasture’s disease, with membranous nephropathy (MN) has been well documented. However, little is known about the clinical and immunological features of patients with such a combination. This study was designed to investigate the clinical and immunological features of anti-GBM patients with MN and to provide insight into the pathogenesis of this rare entity. Eight patients with combined anti-GBM disease and MN were found to have significantly lower levels of serum creatinine, a significantly lower proportion of oliguria/anuria, and significantly better renal outcomes compared with 30 patients with classical anti-GBM disease. Antibody levels against the EBconformational epitope of anti-α3(IV)NC1 were significantly lower in these patients, as was their levels of anti-α3(IV)NC1 immunoglobulin G1 (IgG1) and IgG3. Serum antibodies against the M-type phospholipase A2receptor were undetectable in anti-GBM patients with MN but presented in 13 of the 20 patients with primary MN. Thus, patients with combined anti-GBM disease and MN have distinct clinical features and a different immunological profile of MN.
