Immediate in vivo response of the cortex and the blood-brain barrier following dynamic cortical deformation in the rat.
Immediate in vivo response of the cortex and the blood-brain barrier following dynamic cortical deformation in the rat.
复制标题
大鼠动态皮质变形后皮质和血脑屏障的即时体内反应。
DOI：
10.1016/s0304-3940(98)00853-2
复制
发表时间：
1999
影响因子：
2.5
通讯作者：
Meaney,DF
中科院分区：
文献类型：
--
作者：
Shreiber,DI;Smith,DH;Meaney,DF
尽管已知脑可被创伤期间在撞击时刻启动的机械力损伤，但尚不清楚脑的物理反应如何决定创伤性脑损伤的实验模型中发生的损伤模式。在这项研究中，我们研究了机械反应的大脑技术，创造了一个局灶性损伤大鼠大脑。使用一个短暂的真空脉冲施加到暴露的皮质表面，我们发现，皮质的位移和体内血脑屏障击穿的程度显着相关的真空压力水平。皮质的反应和损伤模式之间的关系指向一个新的机会，通过对模型生物力学的精确理解，以及潜在的改善，防止创伤性脑损伤的手段，在动物模型中的分布和损伤模式的程度进行控制。
Although it is known that the brain can be injured by mechanical forces initiated at the moment of impact during trauma, it is not clear how the physical response of the brain dictates the injury patterns that occur in experimental models of traumatic brain injury. In this study, we investigated the mechanical response of the brain to a technique that creates a focal injury in the rat brain. Using a transient vacuum pulse applied to the exposed cortical surface, we found that the displacement of the cortex and the extent of in vivo blood–brain barrier breakdown were related significantly to the vacuum pressure level. The relationship between the response of the cortex and injury pattern points towards a new opportunity for control of the distribution and extent of injury patterns in animal models through a precise understanding of the model biomechanics, as well as potential improvements in means of preventing traumatic brain injury.