A PROPOSED STRUCTURE FOR THE NUCLEIC ACIDS
A PROPOSED STRUCTURE FOR THE NUCLEIC ACIDS
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DOI：
10.1073/pnas.39.2.84
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发表时间：
1953-01-01
影响因子：
11.1
通讯作者：
COREY, RB
中科院分区：
文献类型：
--
作者：
PAULING, L;COREY, RB
1952年12月31日通讯核酸作为生物体的组成部分，其重要性可与蛋白质相媲美。有证据表明，它们参与细胞分裂和生长过程，参与遗传性状的传递，是病毒的重要成分。了解核酸的分子结构对于了解生命的基本现象是有价值的，我们现在已经利用分子结构的一般原理和有关核酸本身的现有资料，为核酸阐明了一种有希望的结构。结构不是模糊的，而是精确预测的;主要原子的原子坐标见表1。这是第一个精确描述的核酸结构，已经提出了任何研究人员。该结构解释了X射线照片的某些特征;但尚未进行详细的强度计算，因此不能认为该结构已被证明是正确的。结构的形成-直到最近才收集到关于核酸化学性质的相当完整的信息。核酸是巨大的分子，由复杂的单位组成。每个单元由磷酸根离子HPO 4-，糖（核糖核酸中的核糖）
Communicated December 31, 1952 The nucleic acids, as constituents of living organisms, are comparable in importance to the proteins. There is evidence that they are involved in the processes of cell division and growth, that they participate in the transmission of hereditary characters, and that they are important constituents of viruses. An understanding of the molecular structure of the nucleic acids should be of value in the effort to understand the fundamental phe-nomena of life.We have now formulated a promising structure for the nucleic acids, by making use of the general principles of molecular structure and the available information about the nucleic acids themselves. The structure is not a vague one, but is precisely predicted; atomic coordinates for the principal atoms are given in table 1. This is the first precisely described structure for the nucleic acids that has been suggested by any investigator. The struc-ture accounts for some of the features of the x-ray photographs; but de-tailed intensity calculations have not yet been made, and the structure cannot be considered to have been proved to be correct. The Formulation of the Structure.-Only recently has reasonably complete information been gathered about the chemical nature of the nucleic acids. The nucleic acids are giant molecules, composed of complex units. Each unit consists of a phosphate ion, HPO4--, a sugar (ribose in the ribonucleic