The Comprehensive Assessment of Neurodegeneration and Dementia: Canadian Cohort Study
The Comprehensive Assessment of Neurodegeneration and Dementia: Canadian Cohort Study
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DOI：
10.1017/cjn.2019.27
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发表时间：
2019-09-01
影响因子：
3
通讯作者：
Rylett, R. Jane
中科院分区：
文献类型：
--
作者：
Chertkow, Howard;Borrie, Michael;Rylett, R. Jane
背景：加拿大老年神经变性联合会(CCNA)的神经变性和痴呆综合评估(COMPASS-ND)队列研究是一项旨在促进痴呆症研究的全国性倡议，旨在支持CCNA团队的研究议程。这个由2310名患有各种形式的痴呆症和轻度记忆丧失或担忧的深度表型受试者以及认知完好无损的老年受试者组成的越野纵向队列，将检验这些团队产生的假设。方法：作者使用COMPASS-ND方案、初始拨款提案、2017年12月提交给加拿大卫生研究所的第五次半年度CCNA进展报告，以及其他文件，以及实施后的修改和经验教训，创建对此处提供的研究的描述。结果：CCNA COMPASS-ND队列包括来自加拿大各地的参与者，他们患有与神经退行性疾病相关的或存在神经退行性疾病风险的各种认知疾病。他们将接受广泛的实验、临床、成像和遗传学调查，以具体解决人口老龄化中这些疾病的原因、诊断、治疗和预防。来自临床和认知评估、生物显微镜、脑成像、遗传学和脑捐赠的数据将用于测试CCNA研究团队和其他加拿大研究人员产生的假设。这项研究是加拿大关于痴呆症的最全面和最雄心勃勃的研究。最初的数据发布于2018年，到2020年将积累全部队列数据。结论：COMPASS-ND研究数据的可获得性将在未来几年为加拿大的痴呆症研究提供主要刺激。
Background: The Comprehensive Assessment of Neurodegeneration and Dementia (COMPASS-ND) cohort study of the Canadian Consortium on Neurodegeneration in Aging (CCNA) is a national initiative to catalyze research on dementia, set up to support the research agendas of CCNA teams. This cross-country longitudinal cohort of 2310 deeply phenotyped subjects with various forms of dementia and mild memory loss or concerns, along with cognitively intact elderly subjects, will test hypotheses generated by these teams. Methods: The COMPASS-ND protocol, initial grant proposal for funding, fifth semi-annual CCNA Progress Report submitted to the Canadian Institutes of Health Research December 2017, and other documents supplemented by modifications made and lessons learned after implementation were used by the authors to create the description of the study provided here. Results: The CCNA COMPASS-ND cohort includes participants from across Canada with various cognitive conditions associated with or at risk of neurodegenerative diseases. They will undergo a wide range of experimental, clinical, imaging, and genetic investigation to specifically address the causes, diagnosis, treatment, and prevention of these conditions in the aging population. Data derived from clinical and cognitive assessments, biospecimens, brain imaging, genetics, and brain donations will be used to test hypotheses generated by CCNA research teams and other Canadian researchers. The study is the most comprehensive and ambitious Canadian study of dementia. Initial data posting occurred in 2018, with the full cohort to be accrued by 2020. Conclusion: Availability of data from the COMPASS-ND study will provide a major stimulus for dementia research in Canada in the coming years.