Effects of Isoflavone Aglycone Ratio in Lactic Acid-Fermented Soymilk on Hepatic Lipid Metabolism in Rats Fed a High Fat and High Cholesterol Diet
Effects of Isoflavone Aglycone Ratio in Lactic Acid-Fermented Soymilk on Hepatic Lipid Metabolism in Rats Fed a High Fat and High Cholesterol Diet
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DOI：
10.3136/nskkk.60.509
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发表时间：
2013-01-01
期刊：
影响因子：
0.2
通讯作者：
Fukuda, Mitsuru
中科院分区：
文献类型：
--
作者：
Kobayashi, Maki;Sakakibara, Rie;Fukuda, Mitsuru
我们研究了乳酸发酵豆奶中不同比例的异黄酮苷元对高脂高胆固醇饮食大鼠肝脏脂质代谢的影响。雄性SD大鼠(7周龄)饲喂对照饲料(AIN-93g)、高脂高脂饲料、高脂高脂饲料(含低异黄酮苷元比发酵豆奶或高异黄酮苷元比发酵豆奶)5周。两种乳酸发酵豆奶均具有调节脂类代谢的作用，且异黄酮苷元含量高的发酵豆奶的调节作用强于异黄酮苷元含量低的发酵豆奶。有人认为，异黄酮苷元可刺激肝脏的脂质代谢调节作用。
We investigated the effects of different isoflavone aglycone ratios in lactic acid-fermented soymilk on hepatic lipid metabolism in rats fed a high fat and high cholesterol diet. Male Sprague-Dawley rats (7 weeks old) were fed a control diet (AIN-93G), high fat and high cholesterol diet, or high fat and high cholesterol diet containing fermented soymilk with a low isoflavone aglycone ratio or fermented soymilk with a high isoflavone aglycone ratio for 5 weeks. Both lactic acid-fermented soymilks exhibited lipid metabolism-modulating function, and the function was stronger in fermented soymilk with a high isoflavone aglycone ratio than in that with a low isoflavone aglycone ratio. It was proposed that isoflavone aglycones stimulated the lipid metabolism-modulation effects in liver.