Effect of hypoxia and hypercapnic acidosis on renal autoregulation in the dog: role of renal nerves.
Effect of hypoxia and hypercapnic acidosis on renal autoregulation in the dog: role of renal nerves.
复制标题
缺氧和高碳酸血症对狗肾脏自动调节的影响：肾神经的作用。
DOI：
10.1042/cs0650533
复制
发表时间：
1983
期刊：
影响因子：
--
通讯作者：
Zerbe,GG
中科院分区：
文献类型：
--
作者：
Anderson,RJ;Pluss,RG;Pluss,WT;Bell,J;Zerbe,GG
1. 以往的研究表明，缺氧和高碳酸性酸中毒对肾血流动力学功能有肾神经介导的不良影响。因此，我们研究了缺氧和高碳酸酸中毒对麻醉犬肾血流和肾小球滤过率的影响，将肾灌注压从125降低到75 mmHg。为了研究肾神经在这些反应中的作用，对每只动物的有神经和无神经的肾脏进行了配对研究。缺氧（Po243±3mmhg）既不影响肾血流，也不影响肾小球滤过率对肾灌注压降低的反应。高碳酸性酸中毒（Pco271±2 mmHg; pH 7.03±0.01）随着肾灌注压的降低，肾血流量和肾小球滤过率均显著降低。肾去神经可以消除高碳酸血症酸中毒的这种影响。这些结果表明，高碳酸性酸中毒导致肾神经刺激，这阻止了肾灌注压降低时通常发生的肾传入小动脉张力降低。
1. Previous studies suggest that hypoxia and hypercapnic acidosis exert a renal nerve mediated adverse effect on renal haemodynamic function. We therefore examined the effect of hypoxia and hypercapnic acidosis on renal blood flow and glomerular filtration rate responses to lowering renal perfusion pressure from 125 to 75 mmHg in the anaesthetized dog. To study the role of renal nerves in these responses, paired innervated and denervated kidneys were studied in each animal.2. Hypoxia (Po243 ± 3 mmHg) affected neither renal blood flow nor glomerular filtration rate responses to decreasing renal perfusion pressure.3. Hypercapnic acidosis (Pco271 ±2 mmHg; pH 7.03 ± 0.01) significantly decreased both renal blood flow and glomerular filtration rate as renal perfusion pressure was lowered. This effect of hypercapnic acidosis could be abolished by renal denervation.4. These findings suggest that hypercapnic acidosis results in renal nerve stimulation, which prevents the usual decrease in renal afferent arteriolar tone that occurs in response to lowering of renal perfusion pressure.