Multineuronal codes in retinal signaling
Multineuronal codes in retinal signaling
复制标题
DOI：
10.1073/pnas.93.2.609
复制
发表时间：
1996-01-23
影响因子：
11.1
通讯作者：
Meister, M
中科院分区：
文献类型：
--
作者：
Meister, M
视觉世界是通过视神经纤维群中的动作电位模式呈现给大脑的。单神经元记录显示，每个视网膜神经节细胞都具有空间受限的感受野、有限的积分时间和特征光谱灵敏度。总的来说，这些响应特性定义了神经元动作电位传达的视觉信息。由于视神经的大小受到严格限制，人们期望视网膜能够生成视觉场景的高效表示。相比之下，附近神经节细胞的感受野经常重叠，表明视网膜输出信号之间存在很大的冗余。最近的多神经元记录可能有助于解决这个悖论。他们揭示了神经节细胞之间协调一致的放电模式，其中一小群附近的神经元同步放电，延迟只有几毫秒。由于此类放电模式比神经节细胞多得多，因此这种分布式代码可能允许视网膜将大量不同的视觉信息压缩到少量的视神经纤维中。本文将回顾视网膜输出中分布式编码方案的证据。通过简单的例子分析了此类代码的性能限制，说明它们允许在空间和时间分辨率之间进行强有力的权衡。
The visual world is presented to the brain through patterns of action potentials in the population of optic nerve fibers, Single-neuron recordings show that each retinal ganglion cell has a spatially restricted receptive field, a limited integration time, and a characteristic spectral sensitivity, Collectively, these response properties define the visual message conveyed by that neuron's action potentials, Since the size of the optic nerve is strictly constrained, one expects the retina to generate a highly efficient representation of the visual scene. By contrast, the receptive fields of nearby ganglion cells often overlap, suggesting great redundancy among the retinal output signals. Recent multineuron recordings may help resolve this paradox. They reveal concerted firing patterns among ganglion cells, in which small groups of nearby neurons fire synchronously with delays of only a few milliseconds. As there are many more such firing patterns than ganglion cells, such a distributed code might allow the retina to compress a large number of distinct visual messages into a small number of optic nerve fibers. This paper will review the evidence for a distributed coding scheme in the retinal output. The performance limits of such codes are analyzed with simple examples, illustrating that they allow a powerful trade off between spatial and temporal resolution.