X-ray and crystallographic applications in pharmaceutical research. II. Quantitative x-ray diffraction.
X-ray and crystallographic applications in pharmaceutical research. II. Quantitative x-ray diffraction.
复制标题
X 射线和晶体学在药物研究中的应用。
DOI：
10.1002/jps.2600520104
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发表时间：
1963
影响因子：
3.8
通讯作者：
J. W. Shell
中科院分区：
文献类型：
--
作者：
J. W. Shell
在定量方法的比较中，生物测定具有对完整分子具有特异性的优势。然而，这种化验方法往往缺乏高度的精确度。化学方法通常提供高精度，但出了名的非特异性。提供特异性和精确性结合的一般定量方法是非常需要的，特别是用于描述药物系统。这种独特的组合是通过定量x射线衍射对含有晶体成分的系统的适应而发现的。本文介绍了该方法的一般方法和应用于最常见情况的有用程序。说明程序是应用于特定药物系统的例子。
In a comparison of quantitative methods, bioassays have an advantage of being specific for an intact molecule. Such assay methods, however, often lack a high degree of precision. Chemical methods usually offer high precision but are notoriously nonspecific. A general quantitative method which offers a combination of specificity and precision is highly desirable, particularly for use in describing pharmaceutical systems. This unique combination is found by the adaptation of quantitative X-ray diffraction to systems containing crystalline ingredients. This paper describes the general method and the procedures which have been found useful in the application of the method to the most commonly encountered situations. Illustrating the procedures are examples of the applications to specific drug systems.