Thalamocortical Connections of Functional Zones in Posterior Parietal Cortex and Frontal Cortex Motor Regions in New World Monkeys
Thalamocortical Connections of Functional Zones in Posterior Parietal Cortex and Frontal Cortex Motor Regions in New World Monkeys
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DOI：
10.1093/cercor/bhp308
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发表时间：
2010-10-01
期刊：
影响因子：
3.7
通讯作者：
Kaas, Jon H.
中科院分区：
文献类型：
--
作者：
Gharbawie, Omar A.;Stepniewska, Iwona;Kaas, Jon H.
后顶叶皮层（PPC）连接灵长类动物的视觉和运动系统，是视觉引导行动的中心。将PPC的解剖学联系与其神经生理功能联系起来，可能有助于阐明顶额神经网络的组织结构。在猫头鹰和松鼠猴，长时间的电刺激区分PPC和运动/运动前皮质（M1/PM）内的几个功能区。多关节前肢运动让人联想到达到，防御和把握行为的特点，每个功能区。在PPC中，功能区平行于外侧沟组织。用逆行示踪法研究PPC和M1/PM区的丘脑皮质联系。经过几天的示踪剂运输后，处理大脑，并绘制丘脑核中的标记细胞。所有PPC区均接受来自外侧后核和前枕的密集输入。PPC区接受来自运动丘脑腹外侧（VL）分区的额外投射，这也是M1/PM输入的主要来源。头侧运动丘脑向PPC的投射稀疏。丘脑腹后核（VP）的密集投射将头外侧抓握区与其他PPC区区分开来。PPC与VL和VP的连接分别提供了与小脑核和体感系统的联系，这可能将PPC功能与M1/PM整合在一起。
Posterior parietal cortex (PPC) links primate visual and motor systems and is central to visually guided action. Relating the anatomical connections of PPC to its neurophysiological functions may elucidate the organization of the parietal-frontal network. In owl and squirrel monkeys, long-duration electrical stimulation distinguished several functional zones within the PPC and motor/premotor cortex (M1/PM). Multijoint forelimb movements reminiscent of reach, defense, and grasp behaviors characterized each functional zone. In PPC, functional zones were organized parallel to the lateral sulcus. Thalamocortical connections of PPC and M1/PM zones were investigated with retrograde tracers. After several days of tracer transport, brains were processed, and labeled cells in thalamic nuclei were plotted. All PPC zones received dense inputs from the lateral posterior nucleus and the anterior pulvinar. PPC zones received additional projections from ventral lateral (VL) divisions of motor thalamus, which were also the primary source of input to M1/PM. Projections to PPC from rostral motor thalamus were sparse. Dense projections from ventral posterior (VP) nucleus of somatosensory thalamus distinguished the rostrolateral grasp zone from the other PPC zones. PPC connections with VL and VP provide links to cerebellar nuclei and the somatosensory system, respectively, that may integrate PPC functions with M1/PM.