Highly ordered functionalized mesoporous silicate nanoparticles reinforced poly (lactic acid) gatekeeper surface for infection treatment
Highly ordered functionalized mesoporous silicate nanoparticles reinforced poly (lactic acid) gatekeeper surface for infection treatment
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DOI：
10.1016/j.ijbiomac.2020.04.119
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发表时间：
2020-08-01
影响因子：
8.2
通讯作者：
Abdelmonem, Rehab
中科院分区：
文献类型：
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作者：
Abdelbar, Mostafa F.;Shams, Raef S.;Abdelmonem, Rehab
药物的控释被认为是提高治疗效果的递送载体的关键特征。本研究旨在设计和合成纳米花聚乳酸（PLR-NF）在笼状功能化介孔二氧化硅纳米颗粒（SBA15）上的纳米阀盖系统。左旋氯沙（LVX）作为特异性模型药包封在系列上；SBA15， SBA15@NH2和SBA15@NH2/PLA。被检测的纳米载体通过外部刺激以受控的方式释放。基于PLA-NF包被SBAI5@NH2的载药载体，与LVX有效偶联，通过pH调节机制捕获含量高，释放速度快。检测了所选微生物的瓶内释放谱和体外抑菌力。而SBA15@NH2/PLA的孔径、比表面积和孔容分别为5.4 nm、163 nm和0.011 nm，但金黄色葡萄球菌ATCC 6538 （G+ve）、大肠杆菌ATCC 25922 （G-ve）、白色念珠菌ATCC 10231（酵母）和黑曲霉NRRL A-326（真菌）的孔容明显清晰。活力测试证实功能性的增强增强了细胞相容性和无毒性。基于上述有希望的数据，这种类型的纳米载体在与靶向细胞功能化时，提供了将抗生素输送到纳米系统的可达性，以提高抗微生物的效力并减少副作用。(C) 2020 Elsevier B.V.版权所有
The controlled release of a drug considers the key feature of the delivery carrier that enhances therapeutic efficacy. This study was aimed at design, synthesis of nano valve and capping systems onto caged functionalized mesoporous silica nanopartides (SBA15) with nanoflowers polylactic acid (PLR-NF).Levolloxadn (LVX) as a specific model drug was encapsulated onto series; SBA15, SBA15@NH2, and SBA15@NH2/PLA. The examined nanocarriers released in a controlled fashion by external stimuli. The delivery vehicle based on PLA-NF coated SBAI5@NH2, potent conjugated with LVX with experienced a high extent of trapping content with fast releasing by pH regulating mechanism. In vial LVX released profile and in vitro antifungal forceful of the selected microbes were detected. However, SBA15@NH2/PLA exhibited pore size, surface area and pore volume 5.4 nm, 163 and 0.011 respectively, but the significantly clear zone was obtained with Staphylococcus aureus ATCC 6538 (G+ve), Escherichia coli ATCC 25922 (G-ve), Candida albicans ATCC 10231 (yeast) and Aspergillus niger NRRL A-326 (fungus). Viability test avouch that rising functionality enhanced cytocompatibility and non-toxicity profile. Based on the aforementioned promising data, this type of nanocarriers offers when functionalized with targeting cells, the accessibility to deliver antibiotics onto nanosystem for increased potency against microbes and reduce side effects. (C) 2020 Elsevier B.V. All rights reserved.