Association of heart rate variability with occupational and environmental exposure to particulate air pollution
Association of heart rate variability with occupational and environmental exposure to particulate air pollution
复制标题
DOI：
10.1161/hc3401.095038
复制
发表时间：
2001-08-28
期刊：
影响因子：
37.8
通讯作者：
Christiani, DC
中科院分区：
文献类型：
--
作者：
Magari, SR;Hauser, R;Christiani, DC
背景-空气中的颗粒物与过度的发病率和死亡率有关。最近的注意力集中在颗粒物暴露对心脏自主神经控制的影响上。吸入颗粒物可通过引起交感应激反应直接影响自主神经系统，或通过肺部产生的炎性细胞因子间接影响自主神经系统。方法和结果：这项纵向研究调查了一组职业队列(N=40)中直径小于或等于2.5微米的颗粒物(PM2.5)与心率变异性(HRV)的关系。在工作期间和下班后持续监测暴露和心率。PM2.5水平高于波士顿通常报告的环境水平，为0.167+/-3.205 mg/m(3)(几何平均几何标准偏差)。我们发现正常RR间期(SDNN)的5分钟标准偏差(SD)每增加1 mg/m就下降2.66%(95%CI，-3.75%至-1.58%)。(3)4小时移动PM2.5平均值每增加1 mg/m，心率增加1.02%(95%CI，0.59%至1.46%)。SDNN的下降随着平均时间间隔的增加而增大。结论-接触职业和环境PM2.5后，工人心脏自主神经控制发生改变。在作用机制中，似乎有一个长作用(几个小时)和一个短作用(几分钟)的成分，可能分别与细胞因子的产生和交感应激反应有关，或者是在暴露开始后不久开始的累积效应。这些效应在健康的工作人群中的临床意义尚不清楚。
Background-Airborne particulate matter has been linked to excess morbidity and mortality. Recent attention has focused on the effects of particulate exposure on cardiac autonomic control. Inhaled particulates may affect the autonomic nervous system either directly, by eliciting a sympathetic stress response, or indirectly, through inflammatory cytokines produced in the lungs and released into the, circulation.Methods and Results-This longitudinal study examined the association of particulates less than or equal to2.5 mum in diameter (PM2.5) with heart rate variability (HRV) in an occupational cohort (N = 40). Continuous monitoring of exposure and HR was performed during and away from work. PM2.5 levels were higher than ambient levels typically reported in Boston, 0.167 +/- 3.205 mg/m(3) (geometric mean geometric SD). We found a 2.66% decrease (95% CI, -3.75% to -1.58%) in the 5-minute SD of normal RR intervals (SDNN) for every 1 mg/m(3) increase in the 4-hour moving PM2.5 average and a 1.02% increase (95% CI, 0.59% to 1.46%) in HR after adjusting for potential confounding factors. The decrease in SDNN became larger as the averaging interval increased.Conclusions-Workers experienced altered cardiac autonomic control after exposure to occupational and environmental PM2.5. There appears to be either a long-acting (several hours) and a short-acting (several minutes) component to the mechanism of action that may be related to the production of cytokines and the sympathetic stress response, respectively, or a cumulative effect that begins shortly after exposure begins. The clinical significance of these effects in a healthy working population is unclear.