Dental fluorosis: Variability among different inbred mouse strains
Dental fluorosis: Variability among different inbred mouse strains
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DOI：
10.1177/0810794
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发表时间：
2002-11-01
影响因子：
7.6
通讯作者：
Stookey, GK
中科院分区：
文献类型：
--
作者：
Everett, ET;McHenry, MAK;Stookey, GK
与龋齿下降同时出现的是氟斑牙患病率的增加，氟斑牙是牙釉质形成过程中暴露于高于最佳水平的氟化物的副作用。氟斑牙的发病机制尚不清楚。我们假设遗传决定因素影响个体的易感性或耐氟牙症的发展。我们使用小鼠模型系统（门牙的连续萌出）测试了这一假设，其中基因型、年龄、性别、食物、住房和饮用水氟水平可以严格控制。对12个近交系小鼠的检查显示出氟斑牙易感性/抗性的差异。A/J小鼠品系是高度易感的，与其他测试品系相比，氟斑牙的快速发作和严重发展，而129 P3/J小鼠品系受影响最小，具有最小的氟斑牙。这些观察结果支持遗传因素在氟斑牙发病机制中的作用。
Concurrent with the decline in dental caries has been an increase in the prevalence of dental fluorosis, a side-effect of exposure to greater than optimal levels of fluoride during amelogenesis. The mechanisms that underlie the pathogenesis of dental fluorosis are not known. We hypothesize that genetic determinants influence an individual's susceptibility or resistance to develop dental fluorosis. We tested this hypothesis using a mouse model system (continuous eruption of the incisors) where genotype, age, gender, food, housing, and drinking water fluoride level can be rigorously controlled. Examination of 12 inbred strains of mice showed differences in dental fluorosis susceptibility/resistance. The A/J mouse strain is highly susceptible, with a rapid onset and severe development of dental fluorosis compared with that in the other strains tested, whereas the 129P3/J mouse strain is least affected, with minimal dental fluorosis. These observations support the contribution of a genetic component in the pathogenesis of dental fluorosis.