FIBROBLAST CHEMOTAXIS AFTER TENDON REPAIR
FIBROBLAST CHEMOTAXIS AFTER TENDON REPAIR
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DOI：
10.1016/0363-5023(91)90195-h
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发表时间：
1991-07-01
影响因子：
1.9
通讯作者：
AKESON, W
中科院分区：
文献类型：
--
作者：
GELBERMAN, RH;STEINBERG, D;AKESON, W
治疗犬屈肌腱早期控制被动活动。修复部位和近端和远端肌腱残端进行纤维连接蛋白染色，并在第3、7、11和17天进行光镜检查。在修复后的第7天，邻近修复位点的上皮细胞的纤维连接蛋白显著增加，这是上皮细胞活性达到顶峰的时间。到第17天，在修复部位和肌腱残端，纤维连接蛋白染色明显减少。在修复位点附近的内皮细胞中发现了纤维连接蛋白活性的延迟增加。纤维连接蛋白的产生似乎是早期肌腱修复过程的重要组成部分。在损伤和修复后，成纤维细胞的趋化性和对基质的粘附性似乎与纤维连接蛋白的分泌直接相关。本研究首次在临床相关的肌腱修复模型中提供纤维连接蛋白定位的文献。
Healing canine flexor tendons were treated with early controlled passive mobilization. The repair site and proximal and distal tendon stumps were stained for fibronectin and examined by light microscopy at three, seven, eleven, and seventeen days. Fibronectin increased dramatically in the epitenon adjacent to the repair site seven days after repair, a time when epitenon cellular activity was at its peak. By seventeen days, fibronectin staining had decreased substantially, both at the repair site and in the tendon stumps. A delayed increase in fibronectin activity was noted in the endotenon adjacent to the repair site. Fibronectin production appears to be an important component of the early tendon repair process. Fibroblast chemotaxis and adherence to the substratum in the days after injury and repair appears to be related directly to fibronectin secretion. This study is the first to provide documentation of fibronectin localization in a clinically relevant tendon repair model.