Effects of salinity on the chronic toxicity of 4-methylbenzylidene camphor (4-MBC) in the marine copepod Tigriopus japonicus
Effects of salinity on the chronic toxicity of 4-methylbenzylidene camphor (4-MBC) in the marine copepod Tigriopus japonicus
复制标题
盐度对4-甲基亚苄基樟脑(4-MBC)对海洋桡足类虎鱼慢性毒性的影响
DOI：
10.1016/j.aquatox.2021.105742
复制
发表时间：
2021-01-15
影响因子：
4.5
通讯作者：
Shi, Dalin
中科院分区：
文献类型：
--
作者：
Hong, Haizheng;Wang, Jiaxin;Shi, Dalin
有机紫外线过滤剂广泛用于个人护理产品。4-甲基亚苄基樟脑（4-MBC）是最常用的紫外线过滤剂之一。由于4-MBC的广泛使用，在近海沃茨中检测到其高浓度。以往的毒理学研究表明，4-MBC对海洋生物的毒性可能远高于对淡水物种的毒性。为了探索盐度对4-MBC毒性的影响，以海洋桡足类动物虎足类（Tigriopus）作为模式物种，因为它在海洋生态系统中起着重要作用，并且可以适应广泛的盐度条件。T.使鱼适应三种不同的盐度条件（即，20、30和40 ppt），然后暴露于0、1和5 μ g L-1 4-MBC多代（F0-F3）。结果表明，环境相关浓度的4-MBC对T.因此，可能对自然环境中的海洋桡足类构成重大风险。此外，随着盐度的升高，4-MBC对T. - 是的这是因为较高的盐度水平增加了4-MBC的吸收速率常数和生物富集因子，并进一步加剧了4-MBC暴露诱导的氧化应激。- 是的我们的研究表明，了解盐度如何影响4-MBC的毒性对于准确评估4-MBC在水生环境中的风险非常重要。
Organic ultraviolet filters are widely used in personal care products. 4-methylbenzylidene camphor (4-MBC) is one of the most frequently used UV filters. Due to its widespread usage 4-MBC has been detected at high concentrations in offshore waters. Previous toxicological studies have suggested that 4-MBC might induce much higher toxicity in marine organisms than freshwater species. To explore the effects of salinity on 4-MBC toxicity, the marine copepod Tigriopus japonicus was used as the model species, as it plays an important role in marine ecosystems and can be adapted to a wide range of salinity conditions. T. japonicus were adapted to three different salinity conditions (i.e., 20, 30 and 40 ppt) prior to exposure to 0, 1, and 5 mu g L-1 4-MBC for multiple generations (F0-F3). Results showed that environmentally relevant concentrations of 4-MBC had toxic effects on T. japonicus and therefore, can pose a significant risk to marine copepods in the natural environment. In addition, increasing salinity levels increased the lethal, developmental and reproductive toxicities of 4-MBC in T. japonicus. This was because that higher salinity levels increased the uptake rate constant and bioconcentration factor of 4-MBC and also further exacerbated the oxidative stress induced by exposure to 4-MBC in T. japonicus. Our study demonstrated that understanding how salinity affects the toxicity of 4-MBC is important for accurate assessment of the risk of 4-MBC in the aquatic environments.