Cytoarchitecture and Probabilistic Maps of the Human Posterior Insular Cortex
Cytoarchitecture and Probabilistic Maps of the Human Posterior Insular Cortex
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DOI：
10.1093/cercor/bhp208
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发表时间：
2010-06-01
期刊：
影响因子：
3.7
通讯作者：
Amunts, Katrin
中科院分区：
文献类型：
--
作者：
Kurth, Florian;Eickhoff, Simon B.;Amunts, Katrin
在功能成像实验中，人类后岛被证明对各种各样的刺激模式（如疼痛、体感或听觉处理）有反应。虽然在过去的一个世纪里，这个区域的各种解剖图已经出版，但这些方案显示出不同的结果。此外，它们都不能直接与功能成像数据相结合。因此，我们目前对该区域结构-功能关系的了解仍然有限。因此，我们使用观察者独立的方法重新绘制了10个死后大脑的人类岛叶皮层后部。结果显示，脑岛后部有3个不同的细胞结构区。然后对检查的大脑进行三维重建，并将其空间归一化为蒙特利尔神经学研究所的单一受试者模板。通过叠加单个圈定计算每个区域的概率图，并计算细胞建筑汇总图来绘制区域建筑组织。这些图谱可用于识别在神经影像学研究中观察到的功能激活的解剖学相关性，并了解人类后岛功能分离的微观结构相关性。
The human posterior insula was shown to respond to a wide variety of stimulation paradigms (e.g. pain, somatosensory, or auditory processing) in functional imaging experiments. Although various anatomical maps of this region have been published over the last century, these schemes show variable results. Moreover, none can directly be integrated with functional imaging data. Hence, our current knowledge about the structure-function relationships in this region remains limited. We therefore remapped the posterior part of the human insular cortex in 10 postmortem brains using an observer-independent approach. This analysis revealed the existence of 3 cytoarchitectonically distinct areas in the posterior insula. The examined brains were then 3D reconstructed and spatially normalized to the Montreal Neurological Institute single-subject template. Probabilistic maps for each area were calculated by superimposing the individual delineations, and a cytoarchitectonic summary map was computed to chart the regional architectonic organization. These maps can be used to identify the anatomical correlates of functional activations observed in neuroimaging studies and to understand the microstructural correlates of the functional segregation of the human posterior insula.