Feasibility of microwave hyperthermia for brain tumor therapy.
Feasibility of microwave hyperthermia for brain tumor therapy.
复制标题
微波热疗治疗脑肿瘤的可行性。
DOI：
10.1159/000408247
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
Salcman,M
中科院分区：
文献类型：
--
作者：
Salcman,M
We have discussed the biophysical rationale for the use of hyperthermia in the treatment of malignant brain tumors previously [10, 11], but it is necessary to review some of this material briefly so we may present a fair analysis of the unique advantages and disadvantages of microwaves as a putative energy source for thermotherapy. Heat is a physical agent: Its biologic effects are related directly to the duration and intensity of its application [4, 10]. The antineoplastic action of hyperthermia is manifest at 42 C, but as it is a well-documented finding that metabolic damage to normal hepatocytes and neurons occurs at 43 C [8, 14], the therapeutic index for hyperthermia is quite narrow. In the range of 44-45 C, denaturation of protein occurs in both normal and neoplastic cells. Unfortunately, some types of naturally occurring and experimental tumors require temperatures greater than 45 C for significant cellkilling to occur. The very nature of hyperthermia therapy, there-fore, requires precisely delivered, well-controlled, and accurately measured heating capabilities [1, 2].Clinicians have been interested in hyperthermia as an anticancer agent for more than a century, but therapeutic applications have not been developed because of the technologic problem of delivering precisely controlled and well-delimited hyperthermal fields deep within the body [11, 15]. An ideal hyperthermia system is capable of generating such fields at high temperatures without appreciably affecting normal tissues in close proximity to the tumor target. The method of heating should be versatile enough to make practical the other advantages offered by hyperthermia:
