Dark rearing alters the short-term synaptic plasticity in visual cortex.
Dark rearing alters the short-term synaptic plasticity in visual cortex.
复制标题
黑暗饲养会改变视觉皮层的短期突触可塑性。
DOI：
10.1016/j.neulet.2007.05.053
复制
发表时间：
2007
影响因子：
2.5
通讯作者：
Wang,Shi-Qiang
中科院分区：
文献类型：
--
作者：
Tang,Ai-Hui;Chai,Zhen;Wang,Shi-Qiang
所有化学突触的强度都可以通过它们最近的活动迅速上调或下调，以通过短期易化或抑制机制重塑突触后信号。感觉经验对于皮层回路和功能的成熟也是必不可少的。本实验研究了感觉经验对大鼠视皮层脑片短时程可塑性的影响。在第II/III层重复刺激，用全细胞记录法检测第V层锥体神经元的反应。我们通过在黑暗环境中饲养动物来剥夺大鼠的视觉体验。我们发现，暗饲养（DR）对兴奋性突触后电流（EPSC）或抑制性突触后电流（IPSC）的成对脉冲相互作用没有影响。然而，在20 Hz或更高的刺激频率下，DR增加了IPSC稳态抑制的水平。这一结果，以及DR降低视皮层神经回路兴奋性的发现，提示了一种补偿机制，这可能在突触不成熟时增强网络兴奋性方面很重要。
The strength of all chemical synapses can be rapidly up- or down-regulated by their recent activities to reshape the postsynaptic signal through a mechanism of short-term facilitation or depression. It is also true that sensory experience is essential for maturation of cortical circuits and function. We studied the effect of sensory experience on the short-term plasticity in brain slices of rat visual cortex. Repetitive stimulation was applied in layer II/III and the response of pyramidal neuron in layer V was examined by whole-cell recording. We deprived the visual experience of rats by rearing the animals in dark environment. We found that dark rearing (DR) had no effects on paired-pulse interactions of either excitatory postsynaptic currents (EPSCs) or inhibitory postsynaptic currents (IPSCs). However, DR increased the level of IPSCs steady-state depression at stimulation frequency of 20Hz or more. This result, together with the finding that DR reduced the excitability of neural circuit in visual cortex, suggested a compensatory mechanism, which may be important in enhancing the network excitability at a time when synapses are immature.