Multimodal neuroimaging and behavioral assessment of α-synuclein polymorphism rs356219 in older adults.
Multimodal neuroimaging and behavioral assessment of α-synuclein polymorphism rs356219 in older adults.
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DOI：
10.1016/j.neurobiolaging.2018.02.001
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发表时间：
2018-06
影响因子：
4.2
通讯作者：
Vaillancourt DE
中科院分区：
文献类型：
--
作者：
Burciu RG;Seidler RD;Shukla P;Nalls MA;Singleton AB;Okun MS;Vaillancourt DE
The single nucleotide polymorphism rs356219 in the α-synuclein (SNCA) gene has been shown to significantly contribute to an earlier age at onset of Parkinson's disease (PD), regulate SNCA expression in PD-brain regions, blood and plasma. Here, we used multimodal MRI to study healthy adults with and without the rs356219 risk genotype. Motor and cognitive tests were administered and all participants underwent functional and structural MRI. Imaging analyses included: 1) task-based functional MRI, 2) task-based functional connectivity, 3) free-water diffusion MRI of the substantia nigra, 4) voxel-based morphometry, 5) surface-based morphometry. There were no differences between the two groups in motor and cognitive performance, or brain structure. However, carrying a PD risk variant was associated with reduced functional activity in the posterior putamen and primary motor cortex. Moreover, the posterior putamen had reduced functional connectivity with the motor cortex during motor control in those with a risk genotype compared to those without. These findings point to functional abnormalities in the striato-cortical circuit of rs356219 risk genotype carriers.
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影响因子：
--
作者：
Mata, Ignacio F.;Shi, Min;Agarwal, Pinky;Chung, Kathryn A.;Edwards, Karen L.;Factor, Stewart A.;Galasko, Douglas R.;Ginghina, Carmen;Griffith, Alida;Higgins, Donald S.;Kay, Denise M.;Kim, Hojoong;Leverenz, James B.;Quinn, Joseph F.;Roberts, John W.;Samii, Ali;Snapinn, Katherine W.;Tsuang, Debby W.;Yearout, Dora;Zhang, Jing;Payami, Haydeh;Zabetian, Cyrus P.
通讯作者：
Zabetian, Cyrus P.
DOI：
10.1093/brain/awx146
发表时间：
2017-08-01
期刊：
Brain : a journal of neurology
影响因子：
--
作者：
Burciu RG;Ofori E;Archer DB;Wu SS;Pasternak O;McFarland NR;Okun MS;Vaillancourt DE
通讯作者：
Vaillancourt DE
影响因子：
4.8
作者：
Fuchs, Julia;Tichopad, Ales;Gasser, Thomas
通讯作者：
Gasser, Thomas
影响因子：
4.2
作者：
Nalls, Mike A.;Bras, Jose;Singleton, Andrew B.
通讯作者：
Singleton, Andrew B.
影响因子：
5.7
作者：
Dahnke, Robert;Yotter, Rachel Aine;Gaser, Christian
通讯作者：
Gaser, Christian