Neuroprotective effect of law dose riluzole in gerbil model of transient global ischemia
Neuroprotective effect of law dose riluzole in gerbil model of transient global ischemia
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DOI：
10.1016/s0304-3940(00)01536-6
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发表时间：
2000-11-10
影响因子：
2.5
通讯作者：
Roh, JK
中科院分区：
文献类型：
--
作者：
Bae, HJ;Lee, YS;Roh, JK
阿曲唑是一种神经保护剂，其功效已在人类肌萎缩侧索硬化症和脑缺血动物模型中得到证实。然而，动物实验中使用的剂量远高于人体。我们研究了低剂量利鲁唑（与人体试验中使用的剂量相似）在全脑缺血动物模型中的疗效。在直肠温度监测下，在雄性蒙古沙土鼠中诱导全脑缺血5 min。缺血前30分钟腹腔注射利鲁唑（0.8 mg/kg）。缺血后7天，将动物断头，并定量海马CA 1区存活的神经细胞。比较利鲁唑组和对照组细胞存活数，利鲁唑组细胞存活数明显高于对照组（P < 0.001）。(C)2000爱思唯尔科学爱尔兰有限公司保留所有权利。
Riluzole is a neuroprotective agent the efficacy of which was proven in amyotrophic lateral sclerosis in human and in animal models of cerebral ischemia. However, the dosage used in animal experiments was much higher than that in human. We investigated the efficacy of low dose riluzole, which was similar to the dose used in human trials, in animal model of global ischemia. Global ischemia was induced in male Mongolian gerbils for 5 min under monitoring of rectal temperature. Riluzole (0.8 mg/kg) were injected intraperitoneally 30 min before ischemia. Seven days after ischemia, animals were decapitated and surviving nerve cells in hippocampal CA1 area were quantified. The number of surviving cells was compared between in riluzole-treated and control groups a nd the former showed statistically significant better survivals than the latter (P < 0.001). (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.