Mitochondrial Genomic Backgrounds Affect Nuclear DNA Methylation and Gene Expression.
Mitochondrial Genomic Backgrounds Affect Nuclear DNA Methylation and Gene Expression.
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DOI：
10.1158/0008-5472.can-17-1473
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发表时间：
2017-11-15
期刊：
影响因子：
11.2
通讯作者：
Welch DR
中科院分区：
文献类型：
--
作者：
Vivian CJ;Brinker AE;Graw S;Koestler DC;Legendre C;Gooden GC;Salhia B;Welch DR
Mitochondrial DNA (mtDNA) mutations and polymorphisms contribute to many complex diseases, including cancer. Using a unique mouse model that contains nDNA from one mouse strain and homoplasmic mitochondrial haplotypes from different mouse strain(s) - designated Mitochondrial Nuclear Exchange (MNX) – we showed that mtDNA could alter mammary tumor metastasis. Since retrograde and anterograde communication exist between the nuclear and mitochondrial genomes, we hypothesized that there are differential mtDNA-driven changes in nuclear (n)DNA expression and DNA methylation. Genome-wide nDNA methylation and gene expression were measured in harvested brain tissue from paired wild-type and MNX mice. Selective differential DNA methylation and gene expression were observed between strains having identical nDNA, but different mtDNA. These observations provide insights into how mtDNA could be altering epigenetic regulation and thereby contribute to the pathogenesis of metastasis.
