Postmortem MRI and histopathology of white matter changes in Alzheimer brains - A quantitative, comparative study
Postmortem MRI and histopathology of white matter changes in Alzheimer brains - A quantitative, comparative study
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DOI：
10.1159/000057698
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发表时间：
2002-01-01
影响因子：
2.4
通讯作者：
Wahlund, LO
中科院分区：
文献类型：
--
作者：
Bronge, L;Bogdanovic, N;Wahlund, LO
评估阿尔茨海默病患者白色改变的磁共振成像（MRI）是否低估或高估了神经病理学结果。对6例尸检诊断为AD的老年人进行了死后MRI和神经病理学检查。使用专门设计的脑切片机，根据MRI图像切割脑，并用Luxol Fast Blue染色。应用体视学原理对MRI和神经病理学上的白色改变进行定量分析。MRI和病理学测量高度相关（r（2）= 0.71）。然而，在所有病例中，病理学显示出比MRI更广泛的变化，平均面积大54%。然而，MRI未识别的病变仅表现为轻微变化，髓鞘染色强度较低，纤维之间的距离加重，但轴突网络和胶质细胞密度保留。版权所有（C）2002 S. Karger AG，巴塞尔。
To evaluate whether magnetic resonance imaging (MRI) of white matter changes in Alzheimer's disease either under- or overestimates the findings on neuropathology. Postmortem MRI and neuropathological examination were performed on 6 brains from elderly individuals with a postmortem diagnosis of AD. Using a specially designed brain slicer, the brains were cut corresponding to the MRI images, and stained by Luxol Fast Blue. Quantitative analysis of white matter changes on MRI and neuropathology was performed using stereological principles. Measures from MRI and pathology were highly correlated (r(2) = 0.71). However, pathology showed significantly more extensive changes than did MRI in all cases, with a mean of 54% larger areas. The lesions not identified with MRI represented, however, only minor changes with lower intensity of myelin staining and with an accentuation of the distance between fibres but with preserved axonal network and glial cell density. Copyright (C) 2002 S. Karger AG, Basel.