TNFα G308A polymorphism is associated with resilience to sleep deprivation-induced psychomotor vigilance performance impairment in healthy young adults.
TNFα G308A polymorphism is associated with resilience to sleep deprivation-induced psychomotor vigilance performance impairment in healthy young adults.
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TNFα G308A 多态性与健康年轻人对睡眠剥夺引起的精神运动警惕性表现障碍的恢复力相关。
DOI：
10.1016/j.bbi.2014.12.009
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
VanDongen,HansPA
中科院分区：
文献类型：
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作者：
Satterfield,BrieannC;Wisor,JonathanP;Field,StephanieA;Schmidt,MichelleA;VanDongen,HansPA
细胞因子如TNFα在睡眠/觉醒调节中起着不可或缺的作用，最近被假设与睡眠剥夺引起的认知障碍有关。我们研究了TNFα基因第308位鸟嘌呤被腺嘌呤取代（TNFα G308 A）对完全睡眠剥夺时精神警觉性表现损害的影响。共有88名健康女性和男性（年龄22-40岁）参加了五个实验室总睡眠剥夺实验之一。每2-3小时测量一次心理警觉性测试（PVT）的表现。TNFα 308 A等位基因比308 G等位基因少见，在完全睡眠剥夺期间（无论一天中的什么时间），与对精神警觉性表现障碍的更大恢复力相关，并且在基线时也提供了一个小的表现获益。当控制受试者之间的年龄、性别、种族/民族和基线睡眠时间差异时，基因型对弹性的影响仍然存在。TNFα G308 A多态性预测睡眠剥夺期间表现受损的总体受试者间方差小于10%。尽管如此，多态性在性能受损峰值时的差异效应超过当时中位性能受损的50%，与文献中报道的其他基因型的效应相比，这是相当大的。我们的研究结果为TNFα在睡眠剥夺对精神警觉表现的影响中的作用提供了证据。此外，TNFα G308 A多态性在评估睡眠剥夺所致精神警觉性表现障碍的恢复力的生物标志物组中可能具有预测潜力。
Cytokines such as TNFα play an integral role in sleep/wake regulation and have recently been hypothesized to be involved in cognitive impairment due to sleep deprivation. We examined the effect of a guanine to adenine substitution at position 308 in the TNFα gene (TNFα G308A) on psychomotor vigilance performance impairment during total sleep deprivation. A total of 88 healthy women and men (ages 22–40) participated in one of five laboratory total sleep deprivation experiments. Performance on a psychomotor vigilance test (PVT) was measured every 2–3 h. The TNFα 308A allele, which is less common than the 308G allele, was associated with greater resilience to psychomotor vigilance performance impairment during total sleep deprivation (regardless of time of day), and also provided a small performance benefit at baseline. The effect of genotype on resilience persisted when controlling for between-subjects differences in age, gender, race/ethnicity, and baseline sleep duration. The TNFα G308A polymorphism predicted less than 10% of the overall between-subjects variance in performance impairment during sleep deprivation. Nonetheless, the differential effect of the polymorphism at the peak of performance impairment was more than 50% of median performance impairment at that time, which is sizeable compared to the effects of other genotypes reported in the literature. Our findings provided evidence for a role of TNFα in the effects of sleep deprivation on psychomotor vigilance performance. Furthermore, the TNFα G308A polymorphism may have predictive potential in a biomarker panel for the assessment of resilience to psychomotor vigilance performance impairment due to sleep deprivation.