Validation of the Addenbrooke's Cognitive Examination III in Frontotemporal Dementia and Alzheimer's Disease
Validation of the Addenbrooke's Cognitive Examination III in Frontotemporal Dementia and Alzheimer's Disease
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DOI：
10.1159/000351671
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发表时间：
2013-01-01
影响因子：
2.4
通讯作者：
Hodges, John R.
中科院分区：
文献类型：
--
作者：
Hsieh, Sharpley;Schubert, Samantha;Hodges, John R.
背景/目标：本研究的目的是验证新开发的版本的Addenbrooke的认知检查（ACE-III）对标准化的神经心理学测试及其前身（ACE-R）在早期痴呆症。研究方法：本研究共纳入61例痴呆患者（额颞叶痴呆，FTD，n = 33，阿尔茨海默病，AD，n = 28）和25例对照。结果如下：ACE-III认知领域与用于评估注意力、语言、言语记忆和视觉空间功能的标准化神经心理学测试显著相关。ACE-III与其前身ACE-R相比也非常有利，具有相似的敏感性和特异性水平。结论：本研究结果客观验证了ACE-III作为FTD和AD认知缺陷筛查工具的有效性。(C)2013 S. Karger AG，巴塞尔
Background/Aims: The aims of this study were to validate the newly developed version of the Addenbrooke's Cognitive Examination (ACE-III) against standardised neuropsychological tests and its predecessor (ACE-R) in early dementia. Methods: A total of 61 patients with dementia (frontotemporal dementia, FTD, n = 33, and Alzheimer's disease, AD, n = 28) and 25 controls were included in the study. Results: ACE-III cognitive domains correlated significantly with standardised neuropsychological tests used in the assessment of attention, language, verbal memory and visuospatial function. The ACE-III also compared very favourably with its predecessor, the ACE-R, with similar levels of sensitivity and specificity. Conclusion: The results of this study provide objective validation of the ACE-III as a screening tool for cognitive deficits in FTD and AD. (C) 2013 S. Karger AG, Basel