DIFFERENTIAL INTERACTIONS OF PHENCYCLIDINE WITH TETRABENAZINE AND RESERPINE AFFECTING INTRANEURONAL DOPAMINE
DIFFERENTIAL INTERACTIONS OF PHENCYCLIDINE WITH TETRABENAZINE AND RESERPINE AFFECTING INTRANEURONAL DOPAMINE
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DOI：
10.1016/0006-2952(83)90388-x
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发表时间：
1983-01-01
影响因子：
5.8
通讯作者：
BAGCHI, SP
中科院分区：
文献类型：
--
作者：
BAGCHI, SP
研究了苯环利定等兴奋剂与丁苯那嗪、利血平相互作用对大鼠脑突触体（P2）多巴胺的影响。四苯那嗪和利血平均能增强突触体自发释放[14C]多巴胺，抑制[14C]苯丙氨酸生成[14C]多巴胺。四苯那嗪和利血平的共添加对PCP和氨苯酸诱导的[14C]多巴胺形成增加的影响不同。在较低浓度下，丁苯那嗪不影响或增强刺激物对多巴胺形成的增强作用。所有水平的利血平阻断了合成增强，并显示出PCP和氨苯酸对多巴胺形成的抑制作用：只有在较高浓度时，丁苯那嗪的作用才与利血平相似。丁苯那嗪和利血平均对苯丙胺刺激多巴胺形成有影响；刺激要么维持，要么增强。氯胺酮单独、与丁苯那嗪或利血平联用均不影响多巴胺的形成。四苯那嗪和利血平以类似的方式影响突触体多巴胺的形成和释放，但PCP和氨苯酸的神经元内多巴胺能作用可能受到这两种释放剂的不同影响。
The effects on rat brain synaptosomal (P2) dopamine of interactions of phencyclidine [PCP, a major drug of abuse], and some other stimulants with tetrabenazine and reserpine were studied. Tetrabenazine and reserpine both enhanced the spontaneous synaptosomal release of [14C]dopamine and inhibited its formation from [14C]Phe. The [14C]dopamine formation increases induced by PCP and amfonelic acid were affected differentially by the coadditions of tetrabenazine and reserpine. At the lower concentrations, tetrabenazine either did not affect or augmented the dopamine formation enhancements by the stimulants. Reserpine at all levels blocked the synthesis enhancements and revealed inhibitory effects of PCP and amfonelic acid upon dopamine formation: only at the higher concentration did the action of tetrabenazine mimic that of reserpine. Amphetamine stimulation of dopamine formation was affected by tetrabenazine and reserpine alike; the stimulation was either maintained or enhanced. Ketamine did not affect dopamine formation either by itself, with tetrabenazine or with reserpine. Tetrabenazine and reserpine affected synaptosomal dopamine formation and release in a comparable manner, but intraneuronal dopaminergic actions of PCP and also of amfonelic acid may be influenced differentially by these 2 releasing agents.