Innate and Adaptive Immune Responses in Wound Epithelialization
Innate and Adaptive Immune Responses in Wound Epithelialization
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DOI：
10.1089/wound.2012.0435
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发表时间：
2014-07-01
影响因子：
4.9
通讯作者：
Stojadinovic, Olivera
中科院分区：
文献类型：
--
作者：
Strbo, Natasa;Yin, Natalie;Stojadinovic, Olivera
重要性：多年来，人们已经清楚地认识到，除了在免疫防御中履行常规职责外，免疫系统的先天和适应性武器是导致伤口愈合的一系列复杂事件的重要调节器。免疫细胞通过促进细胞间相互作用来调节伤口愈合;它们分泌信号分子，包括细胞因子、趋化因子和生长因子。随着伤口愈合研究的主要努力是为不断增加的慢性伤口患者寻找有效的治疗药物，关于先天性和适应性免疫反应对受损皮肤再上皮化的贡献的发现可能会带来新的治疗方法。越来越多的证据表明，诱导适应性免疫应答需要激活先天免疫，并且先天免疫与免疫应答之间存在依赖关系。两制因此，先天性和获得性免疫系统之间的桥梁已成为一个新兴的探索领域。很明显，更好地了解上皮细胞因此，研究有助于有效伤口愈合过程的细胞（角质形成细胞）、免疫细胞和机制是必要的，这样就可以设计出成功治疗伤口的新策略。对伤口上皮形成过程中皮肤先天性和适应性免疫细胞生物学的更深入理解可能会对开发新策略产生影响，以显著改善伤口上皮形成过程中的皮肤免疫功能。组织修复的质量。未来的方向：未来的研究应该阐明用于皮肤驻留γ δ T和朗格汉斯细胞的发育和功能的特定分子和机制的重要性，以及鉴定用于操纵这些细胞以对抗上皮疾病的治疗靶点。
Significance: Over the years, it has become clear that, in addition to performing their regular duties in immune defense, the innate and adaptive arms of the immune system are important regulators of the complex series of events that lead to wound healing. Immune cells modulate wound healing by promoting cellular cross-talk; they secrete signaling molecules, including cytokines, chemokines, and growth factors. In line with the major effort in wound healing research to find efficient therapeutic agents for the constantly increasing number of patients with chronic wounds, findings regarding the contributions of innate and adaptive immune responses to the re-epithelialization of damaged skin may bring novel therapeutics.Recent Advances: Increasing evidence suggests that induction of the adaptive immune response requires activation of innate immunity and that there is a dependent relationship between the two systems. Consequently, the bridge between the innate and the acquired immune systems has become an area of emerging exploration. It is clear that a better understanding of the epithelial cells (keratinocytes), immune cells, and mechanisms that contribute to an effective wound healing process is necessary so that new strategies for successful wounds treatment can be devised.Critical Issues: A greater understanding of the biology of skin innate and adaptive immune cells during wound epithelialization may have an impact on development of novel strategies for significant improvements in the quality of tissue repair.Future Directions: Future studies should clarify the importance of particular molecules and mechanisms utilized for development and functions of skinresident gamma delta T and Langerhans cells, as well as identify therapeutic targets for manipulation of these cells to combat epithelial diseases.