CELLULAR IMMUNE RESPONSIVENESS OF UVEITIS PATIENTS TO RETINAL S-ANTIGEN
CELLULAR IMMUNE RESPONSIVENESS OF UVEITIS PATIENTS TO RETINAL S-ANTIGEN
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DOI：
10.1016/0002-9394(80)90108-7
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发表时间：
1980-01-01
影响因子：
4.2
通讯作者：
WACKER, WB
中科院分区：
文献类型：
--
作者：
NUSSENBLATT, RB;GERY, I;WACKER, WB
S-抗原是一种从视网膜感光区分离的器官特异性物质，是诱导实验性自身免疫性葡萄膜炎的有效因子。检测了S抗原和其他眼部抗原诱导来自各种眼部炎性疾病患者的淋巴细胞原始细胞转化的能力。从22%的患者的淋巴细胞测试表现出积极的记忆反应，从牛的眼睛制备的S-抗原。对人S抗原的反应与对牛S抗原的反应相同。所有阳性反应者均存在活动性或非活动性视网膜病变。一些后葡萄膜炎患者对视网膜粗提物有反应，但对S-抗原无反应，表明其他视网膜抗原可能仍有待纯化。对照受试者没有表现出阳性免疫反应的S-抗原，也没有前葡萄膜炎患者。这些反应在疾病的发病机制中起一定作用。
S-antigen, an organ-specific substance isolated from the retinal photoreceptor region, was a potent agent for induction of experimental autoimmune uveitis. S-antigen and other ocular antigens were tested for their ability to induce blast transformation of lymphocytes from patients with a variety of ocular inflammatory diseases. Lymphocytes from 22% of patients tested manifested a positive memory response to the S-antigen prepared from bovine eyes. Responses to human S-antigen paralleled those found with the bovine. All with a positive response had active or inactive retinal lesions. Some posterior uveitis patients responded to crude retinal extracts but not to S-antigen, indicating the possible role of other retinal antigens still to be purified. Control subjects did not manifest a positive immune response to the S-antigen, nor did patients with anterior uveitis. These responses play some role in the pathogenesis of the disease.