Structural studies on the murine Ia alloantigens. IV. NH2-terminal sequence analysis of allelic products of the I-A and I-E/C subregions.
Structural studies on the murine Ia alloantigens. IV. NH2-terminal sequence analysis of allelic products of the I-A and I-E/C subregions.
复制标题
鼠 Ia 同种异体抗原的结构研究。
DOI：
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发表时间：
1979
影响因子：
4.4
通讯作者：
Ellen S. Vitetta
中科院分区：
文献类型：
--
作者：
Richard G. Cook;M. Siegelman;J. Capra;Jonathan W. Uhr;Ellen S. Vitetta
Murine Ia alloantigens encoded by the I-A and I-E/C subregions were isolated from radiolabeled splenic lysates and examined by NH2-terminal sequence analysis. Haplotype-associated sequence variation was detected in the beta, but not alpha, subunits of both the A and E/C alloantigens. The A beta-polypeptides from k and b haplotypes show four differences in the 12 positions compared, whereas the E/C beta-polypeptides from k and r haplotypes show two differences in the 13 positions compared. No sequence variation was detected between the Ak and Ab alpha-chains (six positions compared) or between the E/Ck and E/Cr alpha-chains (11 positions compared). Homology relationships between these murine Ia alloantigens and the human Ia (DR) alloantigens are also presented.
