Effects of target-controlled infusion of high-dose naloxone on pain and hyperalgesia in a human thermal injury model: a study protocol: A randomized, double-blind, placebo-controlled, crossover trial with an enriched design.
Effects of target-controlled infusion of high-dose naloxone on pain and hyperalgesia in a human thermal injury model: a study protocol: A randomized, double-blind, placebo-controlled, crossover trial with an enriched design.
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高剂量纳洛酮靶控输注对人体热损伤模型中疼痛和痛觉过敏的影响：研究方案：一项具有丰富设计的随机、双盲、安慰剂对照、交叉试验。
DOI：
10.1097/md.0000000000005336
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发表时间：
2016
期刊：
影响因子：
1.6
通讯作者：
Werner,MadsU
中科院分区：
文献类型：
--
作者：
Springborg,AndersD;Jensen,ElisabethK;Taylor,BradleyK;Werner,MadsU
MU-阿片受体拮抗剂作为揭示内源性阿片系统痛觉调制机制的药理工具，在实验研究中得到了广泛的研究。在啮齿动物中，在炎性损伤消退后给予大剂量的Mu-阿片受体拮抗剂，表明伤害性超敏反应恢复，表明潜在的敏感化被揭开。在最近的一项人类研究中，12名受试者中有4名在注射纳洛酮后7天恢复了作为继发性痛觉过敏区域(SHA)的疼痛过敏。
Mu-opioid-receptor antagonists have been extensively studied in experimental research as pharmacological tools uncovering mechanisms of pain modulation by the endogenous opioid system. In rodents, administration of high doses of mu-opioid-receptor antagonists after the resolution of an inflammatory injury has demonstrated reinstatement of nociceptive hypersensitivity indicating unmasking of latent sensitization. In a recent human study, pain hypersensitivity assessed as secondary hyperalgesia area (SHA), was reinstated 7 days after a mild thermal injury, in 4 out of 12 subjects after a naloxone infusion.