Fish, n-3 Polyunsaturated Fatty Acids, and Cardiovascular Disease
Fish, n-3 Polyunsaturated Fatty Acids, and Cardiovascular Disease
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DOI：
10.1007/978-1-61779-894-8_10
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
C. McEvoy;I. Young;J. Woodside
中科院分区：
文献类型：
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作者：
C. McEvoy;I. Young;J. Woodside
心血管疾病（CVD）是西方世界发病率和死亡率的主要原因[1]。有许多明确的CVD风险因素，包括吸烟，高血压和家族史[2]。在营养方面，高脂肪饮食，特别是饱和脂肪，已被证明与CVD发病率相关[3]。格陵兰爱斯基摩人（因纽特人）尽管摄入了高饱和脂肪，但心血管疾病的发病率很低[4]，这一观察结果引起了科学界和公众对鱼类和鱼油中的n-3脂肪酸在预防和治疗疾病，特别是心血管疾病中的作用的兴趣。在本章中，这些化合物的生物化学和正常饮食摄入量将被讨论，并与CVD审查他们和他们的食物来源的证据。鱼油补充剂和鱼的安全性将被评估，最后考虑鱼和鱼油消费对其他疾病的潜在影响。
Cardiovascular disease (CVD) is a major cause of morbidity and mortality in the western world [1]. There are a number of well-established risk factors for CVD including smoking, hypertension, and family history [2]. In terms of nutrition, a diet high in fat, particularly saturated fat, has been shown to be associated with CVD incidence [3]. The observation that Greenland Eskimos (Inuit) have a low incidence of CVD despite a high saturated fat intake [4] has led to much scientific and public interest in the role ofn-3 fatty acids found in fish and fish oils in the prevention and treatment of disease, and particularly CVD. In this chapter, the biochemistry and normal dietary intake of these compounds will be discussed, and the evidence linking them and their food sources with CVD reviewed. The safety of both fish oil supplements and fish will be assessed, and finally the potential effect of fish and fish oil consumption on other diseases considered.