Junín virus pathogenesis and virus replication.
Junín virus pathogenesis and virus replication.
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Junín病毒发病机理和病毒复制。
DOI：
10.3390/v4102317
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发表时间：
2012-10-19
期刊：
影响因子：
--
通讯作者：
Paessler S
中科院分区：
文献类型：
--
作者：
Grant A;Seregin A;Huang C;Kolokoltsova O;Brasier A;Peters C;Paessler S
胡宁病毒是阿根廷出血热的病原体，可导致严重的发病率和死亡率。该病毒通过宿主啮齿动物排泄物的雾化传播，是阿根廷潮湿的潘帕斯草原的地方病。最近，随着新技术（例如反向遗传学）的发展取得了重大进展，扩大了有关胡宁病毒发病机制和病毒复制的知识。我们将回顾胡宁病毒在各种动物模型中的发病机制以及先天免疫和适应性免疫在感染过程中的作用。我们将重点介绍有关胡宁病毒分子生物学在阐明病毒减毒作用方面的最新研究。我们还将总结目前关于胡宁病毒发病机制的知识，重点关注疫苗和潜在疗法的最新发展。
Junín virus, the etiological agent of Argentine hemorrhagic fever, causes significant morbidity and mortality. The virus is spread through the aerosolization of host rodent excreta and endemic to the humid pampas of Argentina. Recently, significant progress has been achieved with the development of new technologies (e.g. reverse genetics) that have expanded knowledge about the pathogenesis and viral replication of Junín virus. We will review the pathogenesis of Junín virus in various animal models and the role of innate and adaptive immunity during infection. We will highlight current research regarding the role of molecular biology of Junín virus in elucidating virus attenuation. We will also summarize current knowledge on Junín virus pathogenesis focusing on the recent development of vaccines and potential therapeutics.