Regression of a T-cell lymphoma after administration of antithymocyte globulin.
Regression of a T-cell lymphoma after administration of antithymocyte globulin.
复制标题
施用抗胸腺细胞球蛋白后 T 细胞淋巴瘤消退。
DOI：
10.7326/0003-4819-88-6-799
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发表时间：
1978
影响因子：
39.2
通讯作者：
R. Young
中科院分区：
文献类型：
--
作者：
R. Fisher;T. Kubota;G. Mandell;S. Broder;R. Young
1例Sézary综合征患者发生T细胞源性弥漫性未分化淋巴瘤。在对多种化疗药物产生耐药性后，患者接受抗胸腺细胞球蛋白治疗。在8天内观察到淋巴结肿大减少75%，皮肤红斑完全消退。此外，在抗胸腺细胞球蛋白治疗后，循环T细胞的百分比以及这些细胞对植物血凝素和伴刀豆球蛋白A的反应能力降低。患者死于继发于严重血小板减少症的脑内出血。该研究表明，在某些晚期淋巴瘤中，可以通过被动抗体治疗来实现肿瘤溶解。
A patient with Sézary syndrome developed a diffuse undifferentiated lymphoma of T-cell origin. After becoming resistant to multiple chemotherapeutic agents, the patient was treated with antithymocyte globulin. A 75% reduction in adenopathy and complete resolution of skin erythema was observed during an 8-day period. In addition the percent of circulating T cells and the ability of those cells to respond to phytohemagglutinin and concanavalin A were reduced after antithymocyte globulin therapy. The patient died of an intracerebral hemorrhage secondary to profound thrombocytopenia. The study suggests that tumor lysis may be achieved by passive antibody therapy in certain advanced lymphomas.