Prefrontal tDCS is unable to modulate mind wandering propensity or underlying functional or effective brain connectivity.
Prefrontal tDCS is unable to modulate mind wandering propensity or underlying functional or effective brain connectivity.
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DOI：
10.1038/s41598-022-22893-8
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发表时间：
2022-10-26
影响因子：
4.6
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中科院分区：
文献类型：
--
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关于经颅直流电刺激（tDCS）对左背外侧前额叶皮层（前额叶tDCS）调节走神倾向的能力，有相互矛盾的证据。在这里，20名参与者在MRI扫描仪中接受了20分钟的活动和假前额叶tDCS，分为两个单独的阶段（平衡）。在每个疗程中，他们完成了两次持续的注意力反应任务（在tDCS之前和期间），其中包括记录走神的主观反应的探针。通过动态功能网络连通性（dFNC）和动态因果模型分析，我们评估了tDCS对行为反应以及功能和有效动力学的影响，分析了默认模式、显著性和执行控制网络的区域。行为学结果提供了大量证据支持tDCS对任务表现和走神倾向没有影响。同样，我们发现tDCS对潜在大脑状态的频率（频率）或停留时间（花费的时间）没有影响，也没有有效的连接。总的来说，我们的研究结果表明，前额叶tDCS不能调节走神倾向或影响潜在的大脑功能。这扩展了先前的行为复制失败，表明前额叶tDCS可能不会导致自我产生认知过程中大脑活动的细微变化（即在行为阈值下）。
There is conflicting evidence over the ability to modulate mind-wandering propensity with anodal transcranial direct current stimulation (tDCS) over the left dorsolateral prefrontal cortex (prefrontal tDCS). Here, 20 participants received 20-min of active and sham prefrontal tDCS while in the MRI scanner, in two separate sessions (counterbalanced). In each session, they completed two runs of a sustained attention to response task (before and during tDCS), which included probes recording subjective responses of mind-wandering. We assessed the effects of tDCS on behavioural responses as well as functional and effective dynamics, via dynamic functional network connectivity (dFNC) and dynamic causal modelling analyses over regions of the default mode, salience and executive control networks. Behavioural results provided substantial evidence in support of no effect of tDCS on task performance nor mind-wandering propensity. Similarly, we found no effect of tDCS on frequency (how often) or dwell time (time spent) of underlying brain states nor effective connectivity. Overall, our results suggest that prefrontal tDCS is unable to modulate mind-wandering propensity or influence underlying brain function. This expands previous behavioural replication failures in suggesting that prefrontal tDCS may not lead to even subtle (i.e., under a behavioural threshold) changes in brain activity during self-generated cognition.
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