Tribendimidine: great expectations.
Tribendimidine: great expectations.
复制标题
曲苯脒：寄予厚望。
DOI：
10.1016/s1473-3099(16)30231-6
复制
发表时间：
2016
期刊：
影响因子：
--
通讯作者：
R. Bergquist
中科院分区：
文献类型：
--
作者：
R. Bergquist
寄生虫感染在世界上大多数脆弱人口生活的热带地区造成了不成比例的疾病负担。然而，控制由寄生原生动物和蠕虫引起的被忽视的热带病的努力主要是基于化疗——考虑到它在传统和古老医学中的根源，这种方法似乎有些随意。虽然现在已经采用了明确的补救措施，如防治扁虫的吡喹酮、防治体外寄生虫和某些线虫的阿维菌素衍生物，以及防治疟疾的联合疗法，但防治许多寄生虫病的有效药物仍然很少。因此，中国人用三苯二胺的开发和批准是一个至关重要的突破。
Parasitic infections inflict a disproportionate burden of disease in the tropics, where most of the world’s vulnerable populations live. However, efforts to control neglected tropical diseases caused by parasitic protozoa and helminths are mainly based on chemotherapy—an approach that can seem somewhat haphazard in view of its roots in traditional and age-old medicine. Although defined remedies have now been introduced, 1 such as praziquantel against flatworms, avermectin-based derivatives against ectoparasites and some nematodes, and combination therapy against malaria, effective drugs against many parasitic diseases are still scarce. The development and approval of tribendimidine for human use in China2–4 is therefore a breakthrough of vital importance.